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Table 1 EffTox parameters chosen in the Matchpoint trial. These are discussed in the main text

From: Implementing the EffTox dose-finding design in the Matchpoint trial

Notation Interpretation Value
N Total number of patients 30
m Cohort size 3
p E Certainty required to infer dose is threshold efficable 0.03
p T Certainty required to infer dose is threshold tolerable 0.05
\(\underline {{\pi }}_{E}\) Minimum efficacy threshold 0.45
\(\overline {{\pi }}_{T}\) Maximum toxicity threshold 0.4
\({\pi }_{1, E}^{*}\) Required efficacy probability if toxicity is impossible 0.40
\({\pi }_{2, T}^{*}\) Permissible toxicity probability if efficacy guaranteed 0.70