Table 1 EffTox parameters chosen in the Matchpoint trial. These are discussed in the main text
From: Implementing the EffTox dose-finding design in the Matchpoint trial
Notation | Interpretation | Value |
|---|---|---|
N | Total number of patients | 30 |
m | Cohort size | 3 |
p E | Certainty required to infer dose is threshold efficable | 0.03 |
p T | Certainty required to infer dose is threshold tolerable | 0.05 |
\(\underline {{\pi }}_{E}\) | Minimum efficacy threshold | 0.45 |
\(\overline {{\pi }}_{T}\) | Maximum toxicity threshold | 0.4 |
\({\pi }_{1, E}^{*}\) | Required efficacy probability if toxicity is impossible | 0.40 |
\({\pi }_{2, T}^{*}\) | Permissible toxicity probability if efficacy guaranteed | 0.70 |