From: Implementing the EffTox dose-finding design in the Matchpoint trial

Notation | Interpretation | Value |
---|---|---|

N
| Total number of patients | 30 |

m
| Cohort size | 3 |

p
_{
E
}
| Certainty required to infer dose is threshold efficable | 0.03 |

p
_{
T
}
| Certainty required to infer dose is threshold tolerable | 0.05 |

\(\underline {{\pi }}_{E}\) | Minimum efficacy threshold | 0.45 |

\(\overline {{\pi }}_{T}\) | Maximum toxicity threshold | 0.4 |

\({\pi }_{1, E}^{*}\) | Required efficacy probability if toxicity is impossible | 0.40 |

\({\pi }_{2, T}^{*}\) | Permissible toxicity probability if efficacy guaranteed | 0.70 |