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Table 2 Doses under investigation in Matchpoint and the investigators’ prior beliefs on rates of efficacy and toxicity

From: Implementing the EffTox dose-finding design in the Matchpoint trial

Dose-level Daily ponatinib dose (mg) Prior Pr(Eff), η E Prior Pr(Tox), η T
1 7.5 0.2 0.025
2 15 0.3 0.05
3 (start dose) 30 0.5 0.1
4 45 0.6 0.25
  1. Note, the ponatinib dose labelled 7.5mg per day is actually 15mg every other day