Table 2 Doses under investigation in Matchpoint and the investigators’ prior beliefs on rates of efficacy and toxicity
From: Implementing the EffTox dose-finding design in the Matchpoint trial
Dose-level | Daily ponatinib dose (mg) | Prior Pr(Eff), η E | Prior Pr(Tox), η T |
|---|---|---|---|
1 | 7.5 | 0.2 | 0.025 |
2 | 15 | 0.3 | 0.05 |
3 (start dose) | 30 | 0.5 | 0.1 |
4 | 45 | 0.6 | 0.25 |