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Table 3 After observing 3TTT in cohort 1, cohort 2 is recommended to receive dose-level 2

From: Implementing the EffTox dose-finding design in the Matchpoint trial

Cohort 2 outcomes Dose for cohort 3
2NNN 3
2NNE 1
2NNT Stop trial
2NNB 1
2NEE 1
2NET 1
2NEB 1
2NTT Stop trial
2NTB 1
2NBB 1
2EEE 1
2EET 1
2EEB 1
2ETT 1
2ETB 1
2EBB 1
2TTT Stop trial
2TTB 1
2TBB 1
2BBB 1
  1. The dose recommended for cohort 3 depends on the outcomes in cohort 2, as depicted by these dose transition pathways