BMC Medical Research Methodology

Table 3 Mean sample size (S.D.), bias, coverage and RMSE of simulated sample sizes with varying interim sample size estimates and true levels of TPPR when TPR_A= 0.9, TPR_B = 0.81 and Prevalence = 0.45. (N = interim sample size)

From: Sample size re-estimation in paired comparative diagnostic accuracy studies with a binary response

	Mean sample size				Bias
	N = 50	N = 100	N = 150	N = 200	N = 50	N = 100	N = 150	N = 200
TPPR
0.81	217(77)	202(35)	198(23)	205(17)	−0.00091	−0.00027	0.00018	0.00048
0.80	256(114)	241(71)	238(56)	241(48)	−0.00031	0.00035	0.00062	0.00064
0.79	297(139)	283(92)	281(72)	282(62)	−0.00007	0.00069	0.00072	0.00068
0.78	338(155)	326(105)	325(83)	325(70)	0.00045	0.00056	0.00082	0.00062
0.77	381(166)	371(114)	369(89)	369(75)	0.00043	0.00054	0.00058	0.00050
0.76	423(170)	415(118)	413(92)	413(78)	0.00054	0.00035	0.00054	0.00041
0.75	465(171)	460(118)	457(93)	456(79)	0.00069	0.00056	0.00029	0.00033
0.74	506(166)	503(115)	501(91)	500(78)	0.00029	0.00028	0.00031	0.00031
0.73	546(156)	546(107)	545(86)	543(73)	0.00047	0.00045	0.00022	0.00022
0.72	585(143)	588(95)	88(76)	586(65)	0.00043	0.00027	0.00017	0.00022
0.71	621(124)	629(75)	630(59)	629(50)	0.00024	0.00037	0.00033	0.00019
	Coverage				RMSE
	N = 50	N = 100	N = 150	N = 200	N = 50	N = 100	N = 150	N = 200
TPPR
0.81	0.923	0.925	0.924	0.923	80	36	23	18
0.8	0.936	0.937	0.936	0.936	115	71	62	48
0.79	0.942	0.943	0.944	0.943	140	92	72	62
0.78	0.947	0.947	0.947	0.946	156	105	80	70
0.77	0.948	0.948	0.949	0.947	166	114	89	75
0.76	0.949	0.950	0.950	0.949	171	118	92	78
0.75	0.950	0.950	0.949	0.950	171	119	93	79
0.74	0.950	0.950	0.950	0.950	166	115	91	78
0.73	0.950	0.951	0.951	0.951	156	107	86	73
0.72	0.951	0.949	0.950	0.951	143	95	76	65
0.71	0.949	0.949	0.950	0.950	124	75	59	50

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ISSN: 1471-2288

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