Sample size re-estimation in paired comparative diagnostic accuracy studies with a binary response

Table 5 Type I error rate, Mean sample size (S.D.), bias, coverage and RMSE of simulated sample sizes under various simulation settings

	N = 50	N = 100	N = 150	N = 200
	Type I error rate
TPPR
0.81	0.050	0.050	0.050	0.050
0.76	0.050	0.050	0.050	0.050
0.71	0.050	0.050	0.050	0.050
	Mean sample size
TPPR
0.81	304(121)	298(78)	297(61)	296(52)
0.76	463(159)	457(107)	454(84)	453(71)
0.71	627(118)	631(74)	630(58)	629(50)
	Bias
TPPR
0.81	0.00207	0.00224	0.00198	0.00186
0.76	0.00147	0.00110	0.00100	0.00087
0.71	0.00021	0.00023	0.00005	−0.00019
	Coverage
TPPR
0.81	0.952	0.951	0.950	0.951
0.76	0.950	0.949	0.949	0.949
0.71	0.948	0.949	0.950	0.949
	RMSE
TPPR
0.81	164	130	119	115
0.76	168	117	95	83
0.71	118	74	59	50

ISSN: 1471-2288