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Protocol adherence for continuously titrated interventions in randomized trials: an overview of the current methodology and case study

  • F. Lauzier1, 2, 3,
  • N. K. Adhikari4, 5,
  • A. Seely6, 7,
  • K. K. Y. Koo8, 9,
  • E. P. Belley-Côté10, 11,
  • K. E. A. Burns4, 12,
  • D. J. Cook10,
  • F. D’Aragon13, 14,
  • B. Rochwerg10,
  • M. E. Kho15,
  • S. J. W. Oczkowksi10,
  • E. H. Duan10,
  • M. O. Meade10,
  • A. G. Day16,
  • F. Lamontagne11, 14Email author and
  • for ACCADEMY (Academy of Critical Care – Development, Evaluation, and Methodology)
BMC Medical Research MethodologyBMC series – open, inclusive and trusted201717:106

https://doi.org/10.1186/s12874-017-0388-3

Received: 22 February 2017

Accepted: 10 July 2017

Published: 17 July 2017

Back to article

Open Peer Review reports

Pre-publication versions of this article are available by contacting info@biomedcentral.com.

Original Submission
22 Feb 2017 Submitted Original manuscript
1 Apr 2017 Reviewed Reviewer Report - S. Swaroop Vedula
3 Apr 2017 Reviewed Reviewer Report - Yuan Zhang
5 Apr 2017 Reviewed Reviewer Report - Diane Uschner
15 Jun 2017 Author responded Author comments - François Lauzier
Resubmission - Version 2
15 Jun 2017 Submitted Manuscript version 2
6 Jul 2017 Author responded Author comments - François Lauzier
Resubmission - Version 3
6 Jul 2017 Submitted Manuscript version 3
Publishing
10 Jul 2017 Editorially accepted
17 Jul 2017 Article published 10.1186/s12874-017-0388-3

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article are available by contacting info@biomedcentral.com.

You can find further information about the peer review system here.

Authors’ Affiliations

(1)
Department of Medicine, Université Laval, Québec, Canada
(2)
Department of Anesthesiology and Critical Care Medicine, Université Laval, Québec, Canada
(3)
Centre de recherche du CHU de Québec-Université Laval, Axe Santé des Populations et Pratiques Optimales en Santé, Québec, Canada
(4)
Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada
(5)
Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, Canada
(6)
Thoracic Surgery and Critical Care Medicine, University of Ottawa, Ottawa, Canada
(7)
Ottawa Hospital Research Institute, Ottawa, Canada
(8)
Swedish Medical Group, Seattle, USA
(9)
Department of Medicine, Western University, London, Canada
(10)
Departments of Medicine, Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Canada
(11)
Department of Medicine, Université de Sherbrooke, Sherbrooke, Canada
(12)
Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Toronto, Canada
(13)
Department of Anaesthesiology, Université de Sherbrooke, Québec, Canada
(14)
Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Canada
(15)
School of Rehabilitation Science, McMaster University, Hamilton, Canada
(16)
Kingston General Hospital Research Institute, Kingston, Canada

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