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Table 3 Bias and MSE of Hazard ratio for estimation of the association between cumulative drug dose and outcome

From: Statistical methods for elimination of guarantee-time bias in cohort studies: a simulation study

β 0 Cumulative dose Cox regression Time-dependent
Cox regression
Landmark analyses
       τ = 5 τ = 7
   Bias MSE Bias MSE Bias MSE Bias MSE
log(0.015) Low 0.0732 0.0035 0.0009 0.0041 0.0673 0.0062 0.0416 0.0105
Moderate 0.2735 0.0019 0.0005 0.0043 0.0641 0.0043 0.0469 0.0068
High 0.6210 0.0004 0.0419 0.0034 0.0437 0.0174 0.0429 0.0061
log(50.015) Low 0.0822 0.0009 0.0007 0.0012 0.0614 0.0020 0.0352 0.0034
Moderate 0.3002 0.0004 −0.0024 0.0012 0.0585 0.0013 0.0455 0.0023
High 0.6263 0.0001 0.0392 0.0011 0.0377 0.0048 0.0366 0.0019
log(100.015) Low 0.0944 0.0006 0.0011 0.0008 0.0565 0.0016 0.0300 0.0029
Moderate 0.3349 0.0002 −0.0032 0.0009 0.0524 0.0011 0.0461 0.0020
High 0.6331 0.0001 0.0360 0.0009 0.0360 0.0038 0.0338 0.0016
  1. β 0 values represent disease incidence rate, MSE Mean squared error, τ Landmark time
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