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Fig. 2 | BMC Medical Research Methodology

Fig. 2

From: Design considerations and analysis planning of a phase 2a proof of concept study in rheumatoid arthritis in the presence of possible non-monotonicity

Fig. 2

The four true Dose-response profiles used in the simulations. The model profiles include a placebo like flat curve which is denoted in blue and is fixed at āˆ’0.5 for all dose levels, a dose proportional Emax model in red, a log-linear model in green, and a U-Shaped model in purple. The label for the vertical axis is the change in DAS28 score from predose at day 56 post-randomisation

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