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Table 2 Comparison of estimates of HR for ARV obtained by Cox-MSM and standard time-dependent Cox models

From: Performance of the marginal structural cox model for estimating individual and joined effects of treatments given in combination

 

aWeighted model with interaction

Weighted model without interaction

Time dependent Cox model with interaction

Covariates

Hazard ratio

95% CI

P value

Hazard ratio

95% CI

P value

Hazard ratio

95% CI

P value

PI alone vs no treatment

3.99

1.55–10.3

0.004

1.15

0.76–1.74

0.52

3.79

1.53–9.43

0.004

Other ARV alone vs no treatment

1.77

0.91–3.42

0.09

1.15

0.68–1.97

0.60

1.92

1.02–3.61

0.04

PI and Other ARV vs no treatment

1.69

0.84–3.39

0.14

1.32

0.76–2.31

0.33

1.90

1.00–3.68

0.05

  1. Hazard ratios for the causal effects of ARV combinations with and w/o PI versus no treatment on the risk of anal cancer in HIV-infected persons followed for 6,381,871 person-months
  2. aReference method
  3. Bold data indicate that the test was statistically significant