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Table 4 Results of Simulations for Scenario 2

From: A comparison of estimators from self-controlled case series, case-crossover design, and sequence symmetry analysis for pharmacoepidemiological studies

 

Setting

Results of simulations

Methods (Effect measures)

β X

Et C (Days)a

β C3

Mean of estimates (Ratio scale)

Bias (Log scale)

Empirical standard error

Mean squared error

Mean standard error

Coverage (%)

SCCS (IRR)

log(1.0)

15

log(5.0)

1.09

0.0903

0.1540

0.0318

0.1531

88.6

CCO (OR)

   

1.11

0.1017

0.2336

0.0649

0.2297

93.1

SSA (ASR)

   

1.01

0.0145

0.2556

0.0655

0.2583

96.1

SCCS (IRR)

log(3.0)

  

3.32

0.1012

0.0909

0.0185

0.0890

77.0

CCO (OR)

   

3.35

0.1101

0.1963

0.0506

0.1894

92.3

SSA (ASR)

   

3.07

0.0227

0.2159

0.0471

0.2102

94.8

SCCS (IRR)

log(10.0)

  

11.09

0.1036

0.0507

0.0133

0.0510

46.4

CCO (OR)

   

11.35

0.1269

0.1774

0.0475

0.1751

91.0

SSA (ASR)

   

10.19

0.0193

0.1858

0.0349

0.1909

96.1

SCCS (IRR)

log(3.0)

5

 

3.05

0.0171

0.0946

0.0092

0.0963

94.5

CCO (OR)

   

3.11

0.0367

0.2012

0.0418

0.1993

94.8

SSA (ASR)

   

3.06

0.0213

0.2291

0.0529

0.2263

95.1

SCCS (IRR)

 

10

 

3.15

0.0501

0.0911

0.0108

0.0930

90.0

CCO (OR)

   

3.20

0.0643

0.1947

0.0420

0.1942

94.4

SSA (ASR)

   

3.09

0.0286

0.2226

0.0503

0.2193

95.1

SCCS (IRR)

 

20

 

3.50

0.1552

0.0845

0.0312

0.0852

55.0

CCO (OR)

   

3.54

0.1658

0.1830

0.0610

0.1849

88.5

SSA (ASR)

   

3.06

0.0203

0.2055

0.0426

0.2010

95.1

SCCS (IRR)

 

30

 

3.81

0.2401

0.0794

0.0639

0.0790

14.7

CCO (OR)

   

3.54

0.1661

0.1719

0.0571

0.1714

86.4

SSA (ASR)

   

3.05

0.0155

0.1916

0.0369

0.1869

94.6

SCCS (IRR)

 

15

log(0.2)

2.92

−0.0273

0.0977

0.0103

0.0981

95.2

CCO (OR)

   

2.96

−0.0129

0.2017

0.0408

0.1991

94.9

SSA (ASR)

   

3.06

0.0197

0.2392

0.0576

0.2316

95.1

SCCS (IRR)

  

log(0.5)

2.94

−0.0206

0.0972

0.0099

0.0976

95.3

CCO (OR)

   

2.98

−0.0058

0.2001

0.0401

0.1986

95.3

SSA (ASR)

   

3.04

0.0137

0.2265

0.0515

0.2295

95.4

SCCS (IRR)

  

log(2.0)

3.06

0.0209

0.0941

0.0093

0.0946

94.3

CCO (OR)

   

3.11

0.0371

0.1968

0.0401

0.1956

95.0

SSA (ASR)

   

3.06

0.0206

0.2249

0.0510

0.2230

94.6

  1. Abbreviations ASR Adjusted sequence ratio, CCO Case-crossover, IRR Incident rate ratio, OR Odds ratio, SCCS Self-controlled case series, SSA Sequence symmetry analysis
  2. aLength of the period in which the time-varying covariate C3(t) has an effect
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BMC Medical Research Methodology

ISSN: 1471-2288

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