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Table 4 Results of Simulations for Scenario 2

From: A comparison of estimators from self-controlled case series, case-crossover design, and sequence symmetry analysis for pharmacoepidemiological studies

  Setting Results of simulations
Methods (Effect measures) β X Et C (Days)a β C3 Mean of estimates (Ratio scale) Bias (Log scale) Empirical standard error Mean squared error Mean standard error Coverage (%)
SCCS (IRR) log(1.0) 15 log(5.0) 1.09 0.0903 0.1540 0.0318 0.1531 88.6
CCO (OR)     1.11 0.1017 0.2336 0.0649 0.2297 93.1
SSA (ASR)     1.01 0.0145 0.2556 0.0655 0.2583 96.1
SCCS (IRR) log(3.0)    3.32 0.1012 0.0909 0.0185 0.0890 77.0
CCO (OR)     3.35 0.1101 0.1963 0.0506 0.1894 92.3
SSA (ASR)     3.07 0.0227 0.2159 0.0471 0.2102 94.8
SCCS (IRR) log(10.0)    11.09 0.1036 0.0507 0.0133 0.0510 46.4
CCO (OR)     11.35 0.1269 0.1774 0.0475 0.1751 91.0
SSA (ASR)     10.19 0.0193 0.1858 0.0349 0.1909 96.1
SCCS (IRR) log(3.0) 5   3.05 0.0171 0.0946 0.0092 0.0963 94.5
CCO (OR)     3.11 0.0367 0.2012 0.0418 0.1993 94.8
SSA (ASR)     3.06 0.0213 0.2291 0.0529 0.2263 95.1
SCCS (IRR)   10   3.15 0.0501 0.0911 0.0108 0.0930 90.0
CCO (OR)     3.20 0.0643 0.1947 0.0420 0.1942 94.4
SSA (ASR)     3.09 0.0286 0.2226 0.0503 0.2193 95.1
SCCS (IRR)   20   3.50 0.1552 0.0845 0.0312 0.0852 55.0
CCO (OR)     3.54 0.1658 0.1830 0.0610 0.1849 88.5
SSA (ASR)     3.06 0.0203 0.2055 0.0426 0.2010 95.1
SCCS (IRR)   30   3.81 0.2401 0.0794 0.0639 0.0790 14.7
CCO (OR)     3.54 0.1661 0.1719 0.0571 0.1714 86.4
SSA (ASR)     3.05 0.0155 0.1916 0.0369 0.1869 94.6
SCCS (IRR)   15 log(0.2) 2.92 −0.0273 0.0977 0.0103 0.0981 95.2
CCO (OR)     2.96 −0.0129 0.2017 0.0408 0.1991 94.9
SSA (ASR)     3.06 0.0197 0.2392 0.0576 0.2316 95.1
SCCS (IRR)    log(0.5) 2.94 −0.0206 0.0972 0.0099 0.0976 95.3
CCO (OR)     2.98 −0.0058 0.2001 0.0401 0.1986 95.3
SSA (ASR)     3.04 0.0137 0.2265 0.0515 0.2295 95.4
SCCS (IRR)    log(2.0) 3.06 0.0209 0.0941 0.0093 0.0946 94.3
CCO (OR)     3.11 0.0371 0.1968 0.0401 0.1956 95.0
SSA (ASR)     3.06 0.0206 0.2249 0.0510 0.2230 94.6
  1. Abbreviations ASR Adjusted sequence ratio, CCO Case-crossover, IRR Incident rate ratio, OR Odds ratio, SCCS Self-controlled case series, SSA Sequence symmetry analysis
  2. aLength of the period in which the time-varying covariate C3(t) has an effect