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Results of simulations


Methods
(Effect measures)

Days of risk

Mean of estimates
(Ratio scale)

Bias (Log scale)

Empirical standard error

Mean squared error

Mean standard error

Coverage (%)


SCCS (IRR)

5

2.89

−0.0377

0.1729

0.0313

0.1661

95.0

CCO (OR)
 
0.99

−1.1068

0.2420

1.2835

0.2406

0.5

SSA (ASR)
 
3.14

0.0466

0.4511

0.2056

0.4076

94.6

SCCS (IRR)

25

2.19

−0.3134

0.0907

0.1065

0.0878

4.4

CCO (OR)
 
2.21

−0.3056

0.1616

0.1195

0.1605

50.3

SSA (ASR)
 
2.23

−0.2981

0.1891

0.1246

0.1829

60.2

 Abbreviations ASR Adjusted sequence ratio, CCO Casecrossover, IRR Incident rate ratio, OR Odds ratio, SCCS Selfcontrolled case series, SSA Sequence symmetry analysis