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Table 8 Results of Simulations to Evaluate the Influence of Misspecified Risk Periods

From: A comparison of estimators from self-controlled case series, case-crossover design, and sequence symmetry analysis for pharmacoepidemiological studies

  Settings Results of simulations
Methods (Effect measures) Days of risk Mean of estimates (Ratio scale) Bias (Log scale) Empirical standard error Mean squared error Mean standard error Coverage (%)
SCCS (IRR) 5 2.89 −0.0377 0.1729 0.0313 0.1661 95.0
CCO (OR)   0.99 −1.1068 0.2420 1.2835 0.2406 0.5
SSA (ASR)   3.14 0.0466 0.4511 0.2056 0.4076 94.6
SCCS (IRR) 25 2.19 −0.3134 0.0907 0.1065 0.0878 4.4
CCO (OR)   2.21 −0.3056 0.1616 0.1195 0.1605 50.3
SSA (ASR)   2.23 −0.2981 0.1891 0.1246 0.1829 60.2
  1. Abbreviations ASR Adjusted sequence ratio, CCO Case-crossover, IRR Incident rate ratio, OR Odds ratio, SCCS Self-controlled case series, SSA Sequence symmetry analysis