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Table 2 Parameter estimates for the pairwise comparison between on-demand (OD) and tailored prophylaxis (TP)

From: Value of information methods to design a clinical trial in a small population to optimise a health economic utility function

Parameter

Estimates

Population size, N

4000

Prior mean, μ0=λ(μTP−μOD), ($)

96000

Prior variance, \(\sigma _{0}^{2}=\lambda ^{2}\left (\sigma ^{2}_{0,\text {TP}}+\sigma ^{2}_{0,\text {OD}}\right)\), ($)

(49638)2

Sample variance, \(\tau ^{2}=2\lambda ^{2}\left (\sigma ^{2}_{\text {TP}}+\sigma ^{2}_{\text {OD}}\right)\), ($)

(363202)2

Cost of conducting the trial per patient, c1, ($)

5000

Cost of treating a patient, c2=c2,TP−c2,OD, ($)

61032

Fixed financial cost incurred from conducting the trial, c f , ($)

1 million