Transition |  | From begin of CTx to ED | From begin of CTx to both LR and DM or DM only | From 6 < CTx < 12 to LD | From CTx = 12 to both LR and DM or DM only | ||||
---|---|---|---|---|---|---|---|---|---|
A | |||||||||
Risk factor | Categories | HR (95%CI) | p | HR (95%CI) | p | HR (95%CI) | p | HR (95%CI) | p |
Age (per 10Â yrs) | Â | 0.91 (0.69; 1.2) | 0.512 | 1.06 (0.69; 1.62) | 0.794 | 1.05 (0.81; 1.36) | 0.709 | 1.03 (0.79; 1.34) | 0.821 |
Gender | male | 1 | Â | 1 | Â | 1 | Â | 1 | Â |
female | 1.47 (0.9; 2.4) | 0.125 | 1.72 (0.8; 3.71) | 0.167 | 0.69 (0.43; 1.13) | 0.142 | 0.81 (0.5; 1.31) | 0.396 | |
Grading | 1 + 2 | 1 |  | 1 |  | 1 |  | 1 |  |
3 + 4 | 0.78 (0.42; 1.45) | 0.431 | 2.03 (0.9; 4.58) | 0.089 | 1.28 (0.78; 2.08) | 0.331 | 0.86 (0.5; 1.48) | 0.59 | |
UICC Stage | II | 1 | Â | 1 | Â | 1 | Â | 1 | Â |
IIIa | 1.42 (0.65; 3.1) | 0.381 | 0.49 (0.06; 4.16) | 0.516 | 0.74 (0.3; 1.79) | 0.499 | 1.31 (0.55; 3.15) | 0.544 | |
IIIb | 1.06 (0.57; 1.98) | 0.846 | 1.05 (0.33; 3.3) | 0.94 | 1.14 (0.66; 1.98) | 0.643 | 2.38 (1.31; 4.35) | 0.005 * | |
IIIc | 1.01 (0.52; 1.98) | 0.969 | 2.16 (0.78; 6.03) | 0.14 | 1.56 (0.9; 2.7) | 0.116 | 3.37 (1.82; 6.23) | < 0.001 * | |
BMI (per kg/m2) | Â | 0.99 (0.93; 1.06) | 0.831 | 0.92 (0.83; 1.02) | 0.116 | 0.98 (0.92; 1.04) | 0.467 | 1 (0.94; 1.06) | 0.982 |
Adjuvant CTx | 5-FU | 1 | Â | 1 | Â | 1 | Â | 1 | Â |
5-FU + FA | 1.01 (0.54; 1.88) | 0.982 | 0.72 (0.31; 1.69) | 0.452 | 1.12 (0.68; 1.86) | 0.661 | 0.92 (0.55; 1.53) | 0.747 | |
5FU + IFN- α | 1.66 (0.92; 3.02) | 0.094 | 0.6 (0.21; 1.71) | 0.34 | 1.38 (0.8; 2.4) | 0.25 | 0.96 (0.54; 1.72) | 0.886 | |
Operation type | Abd. | 1 | Â | 1 | Â | 1 | Â | 1 | Â |
amp.Anterior res. | 0.81 (0.49; 1.33) | 0.4 | 0.72 (0.33; 1.6) | 0.424 | 1.04 (0.66; 1.62) | 0.874 | 0.79 (0.5; 1.24) | 0.307 | |
B | |||||||||
Transition | Â | From ED to both LR and DM or DM only | From LD to both LR and DM or DM only | From LR to death | From both LR and DM or DM only to death | ||||
Risk factor | Categories | HR (95%CI) | p | HR (95%CI) | p | HR (95%CI) | p | HR (95%CI) | p |
Age (per 10Â yrs) | Â | 1.01 (0.66; 1.53) | 0.977 | 0.86 (0.58; 1.28) | 0.462 | 1.85 (0.91; 3.76) | 0.089 | 1.16 (0.96; 1.4) | 0.125 |
Gender | male | 1 | Â | 1 | Â | 1 | Â | 1 | Â |
female | 0.88 (0.34; 2.3) | 0.794 | 0.95 (0.42; 2.14) | 0.894 | 4.62 (1.54; 13.89) | 0.006 * | 1.2 (0.83; 1.73) | 0.325 | |
Grading | 1 + 2 | 1 |  | 1 |  | 1 |  | 1 |  |
3 + 4 | 0.9 (0.32; 2.59) | 0.85 | 1.28 (0.64; 2.56) | 0.478 | 1.43 (0.32; 6.38) | 0.636 | 1.07 (0.73; 1.55) | 0.737 | |
UICC Stage | II | 1 | Â | 1 | Â | 1 | Â | 1 | Â |
IIIa | 0.63 (0.07; 5.34) | 0.672 | 1.12 (0.21; 5.86) | 0.891 | 0.91 (0.19; 4.44) | 0.907 | 1.09 (0.52; 2.28) | 0.815 | |
IIIb | 1.37 (0.4; 4.66) | 0.616 | 2.65 (0.97; 7.25) | 0.059 | 0.76 (0.18; 3.22) | 0.705 | 1.18 (0.72; 1.93) | 0.516 | |
IIIc | 3.55 (1.16; 10.86) | 0.026 * | 5.33 (2; 14.19) | 0.001 * | 2.82 (0.54; 14.86) | 0.221 | 1.72 (1.08; 2.75) | 0.023 * | |
BMI (per kg/m2) | Â | 0.94 (0.83; 1.07) | 0.356 | 0.94 (0.84; 1.06) | 0.306 | 0.94 (0.83; 1.05) | 0.265 | 0.97 (0.93; 1.02) | 0.208 |
Adjuvant CTx | 5-FU | 1 | Â | 1 | Â | 1 | Â | 1 | Â |
5-FU + FA | 2.4 (0.78; 7.33) | 0.126 | 0.53 (0.25; 1.13) | 0.102 | 0.91 (0.23; 3.5) | 0.885 | 1.29 (0.88; 1.88) | 0.186 | |
5FU + IFN-α | 0.66 (0.19; 2.36) | 0.524 | 0.82 (0.35; 1.91) | 0.639 | 0.69 (0.25; 1.96) | 0.491 | 1.28 (0.82; 2) | 0.284 | |
Operation type | Abd. amp. | 1 | Â | 1 | Â | 1 | Â | 1 | Â |
Anterior res. | 0.67 (0.25; 1.77) | 0.417 | 0.37 (0.19; 0.72) | 0.003 * | 0.74 (0.23; 2.41) | 0.618 | 0.85 (0.6; 1.21) | 0.37 |