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Fig. 3 | BMC Medical Research Methodology

Fig. 3

From: Simulation-based power calculations for planning a two-stage individual participant data meta-analysis

Fig. 3

Simulation-based power estimates for the planned IPD random effects meta-analysis* of 24 trials for detecting a treatment-BMI interaction when the true effect was − 0.1, conditional on a range of values of the between-study standard deviation (τ λ ) of the interaction effect, and a particular % reduction in residual variances in each trial due to the inclusion of prognostic factors. *Based on using change score model (4) in each trial followed by random effects meta-analysis model (9) with DerSimonian and Laird estimation, and p-values and CIs derived using approach of Hartung-Knapp Sidik-Jonkman

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BMC Medical Research Methodology

ISSN: 1471-2288

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