Fig. 3

Transformed RESULT values graphed versus Time. Values above the ULN are marked by a blue “+”, RESULT values below the LLN are marked by a black “▼”, and values between and inclusive of the LLN and ULN are designated by an orange “”. Reference lines (^___) are provided at Y-Axis at (0, 1) for the ULN and (0, − 1) for the LLN. Black arrows points to the points corresponding to inverted purple triangles (“”) where the multiple of the LLN for RESULTS of zero were imputed and to inverted light blue triangles representing the value of MI_max, the abnormal low value furthest from the LLN (“”). Abbreviations – H, abnormally high RESULT, L, abnormally low result; Max MI, maximal value of the multiplicative inverse of the LLN; N, normal RESULT