Authors | Treatment | N | Median PFS (months) | Median Age (years) | Median number of previous lines | Mean baseline disease stageb | Female (%) |
---|---|---|---|---|---|---|---|
RCT trials | |||||||
Chanan-Khan et al. [48] | 1. ob7mg + dex40mg | 110 | 3.09 | 62 | 3 | 2.6 | 46 |
2. dex40mg | 114 | 3.55 | |||||
Chiou et al. [49] | 1. thal100mg + IFN | 16 | 1.5 | 63c | 1 | NR | 14 |
2. thal100mg | 12 | 7.9 | |||||
Dimopoulos et al. [50] | 1.bor1.3 mg/m2 + vor400mg | 317 | 7.63 | 62 | 2 | 1.9 | 41 |
2. bor1.3 mg/m2 | 320 | 6.83 | |||||
Dimopoulos et al. [51] | 1. len25mg + dex40mg | 176 | 11.3 | 63 | NR | 2.6 | 41 |
2. dex40mg | 175 | 4.7 | |||||
Dimopoulos et al. [52] | 1. carf20mg + dex20mg | 464 | 18.7 | 65 | 2 | 1.8 | 51 |
2. bor1.3 mg/kg + dex20mg | 465 | 9.4 | |||||
Hjorth et al. [53] | 1. thal50mg + dex40mg | 67 | 9 | 71 | NR | NR | 47 |
2. bor1.3 mg/m2 + dex20mg | 64 | 7.2 | |||||
Kropff et al. [54] | 1. dex40mg | 126 | 6 | 64 | 1–3 prior lines | 1.9 | 57 |
2. thal100/200/400 mga | 373 | 7.4 | |||||
Kropff et al. [55] | 1. bor1.3 mg/kg + dex20mg | 43 | 12.6 | 71 | 1 | 2.1 | 43d |
2. bor1.3 mg/kg + dex20mg + cyc50mg | 47 | 9.9 | |||||
Lonial et al. [56] | 1. elo10mg/kg + len25mg + dex40mg | 321 | 19.4 | 66 | 2 | 1.8 | 40.4d |
2.len25mg + dex40mg | 325 | 14.9 | |||||
Moreau et al. [57] | 1. ixa4mg + len25mg + dex40mg | 360 | 20.6 | 66 | 1 | NR | 43d |
2. len25mg + dex40mg | 363 | 14.7 | |||||
Orlowski et al. [58] | 1. sil6mg + bor1.3 mg/m2 + dex40mg | 142 | 8.1 | 62 | 1–3 prior lines | NR | NR |
2. bor1.3 mg/m2 + dex40mg | 144 | 7.6 | |||||
Orlowski et al. [59] | 1. bor1.3 mg/m2 | 322 | 6.5 | 61 | NR | NR | 44 |
2. PLD20mg + bor1.3 mg/m2 | 324 | 9 | |||||
Palumbo et al. [60] | 1.elo10mg + bor1.3 mg/m2 + dex20mg | 77 | 9.9 | 66 | 1d | NR | 48d |
2. bor1.3 mg/m2 + dex20mg | 75 | 6.8 | |||||
Richardson et al. [61] | 1. pom4mg | 108 | 2.7 | 63 | 5 | 2.6 | 46 |
2. pom4mg + dex40mg | 113 | 4.2 | |||||
Nagler et al. [62] | 1.peri50mg + bor1.3 mg/m2 + dex20mg | 69 | 5.23 | NR | 1d | NR | 68 |
2. bor1.3 mg/m2 + dex20mg | 66 | 8.29 | |||||
Richardson et al. [63] | 1. bor1.3 mg/m2 | 333 | 6.22 | 61 | 2 | NR | 42 |
2. dex40mg | 336 | 3.49 | |||||
San Miguel et al. [64] | 1.pan20mg + bor1.3 mg/m2 + dex20mg | 387 | 12 | 63 | 1 | 1.8 | 47 |
2. bor1.3 mg/m2 + dex20mg | 381 | 8.1 | |||||
San Miguel et al. [14] | 1. pom4mg + dex40mg | 302 | 4 | 64 | 5 | 2 | 41 |
2. dex40mg | 153 | 1.9 | |||||
1.carf20-17 mg + len25mg + dex40mg | 396 | 26.3 | 64 | 2 | NR | 44 | |
2. len25mg + dex40mg | 396 | 17.6 | |||||
Weber et al. [66] | 1. len25mg + dex40mg | 177 | 11.1 | 63 | 1–3 prior lines | 2.5 | 40 |
2. dex40mg | 176 | 4.7 | |||||
White et al. [67] | 1. bor1.3 mg/m2 | 53 | 5.1 | 65 | 1–3 prior lines | 2.1 | 42 |
2. bor1.3 mg/m2 + bev400mg | 49 | 6.2 | |||||
Hou et al. [68] | 1. ixa + len + dex | 57 | 6.7 | NR | 2 | 1.7 | 31 |
2. len + dex | 58 | 4.0 | |||||
Dimopoulos et al. [69] | 1. dara16mg/m2+ len25mg + dex40mg | 286 | 54.1 | 65 | 1 | 1.7 | NR |
2. len25mg + dex40mg | 283 | 18.4 | |||||
Garderet et al. [70] | 1. bor1.3 mg/m2 + thal200mg + dex40mg | 135 | 18.3 | 61 | 1 | 1.6 | 37 |
2. thal200mg + dex40mg | 134 | 13.6 | |||||
Palumbo et al. [71] | 1. dara 16 mg/m2 + bor1.3 mg/m2 + dex20 mg | 251 | 18.5 | 64 | 2 | 1.8 | 43 |
2. bor1.3 mg/m2 + dex20 mg | 247 | 7.2 | |||||
Observational trials | |||||||
Avet-Loiseau et al. [40] | dex40mg + len25mg | 207 | 9.6 | 65 | 3 | 1.7 | 44 |
Chang et al. [41] | bor1.3 mg/m2 | 65 | 9.5 | 54 | > = 2 | 1.3 | 31 |
Fukushima et al. [72] | bor1.3 mg/m2 + dex20mg | 22 | 16.8 | 69 | 2 | 2.1 | 41 |
Hou et al. [73] | dex20/40 mg + len25mg | 199 | 8.3 | 60 | 4 | 2.8 | 47 |
Kneppers et al. [42] | dex40mg + len25mg | 117 | 10 | 61 | 3.5 | 2.7 | 37 |
Lacy et al. [74] | dex40mg + pom2mg | 34 | 4.8 | 62 | 4 | 1.7 | 32 |
Moore et al. [43] | bor1.3 mg/m2 | 52 | 13 | 72 | 1 | 2.6 | 40 |
Oehrlein et al. [75] | Dex < 160-480 mg | 26 | 11.6 | 71 | 2 | 2.8 | 54 |
Len10-25 mg | |||||||
Pantani et al. [76] | bor1.3 mg/m2 + dex20mg | 85 | 8.7 | 58 | 2 | 2.4 | 40 |
Richardson et al. [77] | bor1.3 mg/m2 + dex40mg + pan20mg | 55 | 5.4 | 61 | 4 | 1.9 | 47 |
Terpos et al. [78] | dex40mg + thal200mg | 35 | 8 | 63 | 2 | 2.2 | 34 |
Walter-Croneck et al. [44] | bor1.3 mg/m2 | 708 | 14 | 60 | 1 | 2.1 | 55 |