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Table 6 Synthesis of ICERs from the included intervention studies when available with more than one comparison

From: Cost-effectiveness of diagnostic and therapeutic interventions for chronic hepatitis C: a systematic review of model-based analyses

Genotype Response Population Treatment n Mean 95% CI
1 Tx Naïve All Patients SOF PEG RBV 12 wk. vs BOC PEG RBV 48 wk 5 $18,499.62 6871.38; 30,127.86
1 Tx Naïve All Patients SOF PEG RBV 12 wk. vs PEG RBV 48 wk 5 $26,460.59 18,342.69; 34,578.49
2 Tx Naïve All Patients SOF RBV 12 wk. vs PEG RBV 24 wk 5 $88,099.60 68,301.59; 107,897.61
3 Tx Naïve All Patients SOF PEG RBV 12 wk. vs PEG RBV 24 wk 4 $41,080.16 28,962.61; 53,197.71
3 Tx Experienced All Patients SOF PEG RBV 12 wk. vs PEG RBV 48 wk 4 $29,092.09 9276.64; 48,907.54
1 Tx Naïve All Patients SOF PEG RBV 12 wk. vs TEL PEG RBV 48 wk 3 $25,954.71 − 242.37; 52,151.79
1 Tx Naïve All Patients SOF RBV 24 wk. vs No Tx 3 $61,607.34 43,706.46; 79,508.22
2 Tx Naïve All Patients SOF RBV 12 wk. vs No Tx 3 $13,411.94 6648.19; 20,175.69
2 Tx Experienced All Patients SOF RBV 12 wk. vs PEG RBV 48 wk 3 $38,521.07 8866.40; 68,175.74
3 Tx Naïve With Cirrhosis SOF PEG RBV 12 wk. vs PEG RBV 24 wk 3 $15,496.88 5997.08; 24,996.68
3 Tx Experienced All Patients SOF RBV 24 wk. vs No Tx 3 $34,349.09 23,903.12; 44,795.06
3 Tx Experienced With Cirrhosis SOF RBV 24 wk. vs No Tx 3 $61,199.47 −11,419.99; 133,818.93
3 Tx Naïve All Patients SOF RBV 24 wk. vs No Tx 3 $26,708.10 20,272.80; 33,143.40
3 Tx Naïve With Cirrhosis SOF RBV 24 wk. vs No Tx 3 $16,688.78 5501.36; 27,876.20
1 Tx Experienced With Cirrhosis SOF PEG RBV 12 wk. vs BOC PEG RBV 48 wk 2 $8155.21 − 6369.20; 22,679.62
1 Tx Naïve With Cirrhosis SOF PEG RBV 12 wk. vs BOC PEG RBV 48 wk 2 $14,343.01 2811.59; 25,874.43
1 Tx Experienced All Patients SOF PEG RBV 12 wk. vs PEG RBV 48 wk 2 $16,338.76 − 9294.13; 41,971.65
1 Tx Experienced With Cirrhosis SOF PEG RBV 12 wk. vs PEG RBV 48 wk 2 $9308.71 − 6564.02; 25,181.44
1 Tx Naïve With Cirrhosis SOF PEG RBV 12 wk. vs PEG RBV 48 wk 2 $14,480.59 10,944.65; 18,016.53
1 Tx Naïve With Cirrhosis SOF RBV 24 wk. vs No Tx 2 $45,242.13 19,014.80; 71,469.46
2 Tx Experienced All Patients SOF RBV 12 wk. vs No Tx 2 $16,839.10 13,661.57; 20,016.63
2 Tx Experienced With Cirrhosis SOF RBV 12 wk. vs No Tx 2 $20,559.84 5250.75; 35,868.93
2 Tx Naïve With Cirrhosis SOF RBV 12 wk. vs No Tx 2 $12,953.61 3499.67; 22,407.55
2 Tx Naïve Without Cirrhosis SOF RBV 12 wk. vs No Tx 2 $31,518.88 − 3263.39; 66,301.15
2 Tx Naïve With Cirrhosis SOF RBV 12 wk. vs PEG RBV 24 wk 2 $33,523.44 21,330.96; 45,715.92
3 Tx Experienced All Patients SOF PEG RBV 12 wk. vs No Tx 2 $16,543.85 9323.35; 23,764.35
3 Tx Naïve Without Cirrhosis SOF PEG RBV 12 wk. vs PEG RBV 24 wk 2 $162,539.68 −43,346.34; 368,425.70
3 Tx Experienced Without Cirrhosis SOF RBV 24 wk. vs No Tx 2 $87,973.28 − 4537.35; 180,483.91
3 Tx Naïve Without Cirrhosis SOF RBV 24 wk. vs No Tx 2 $52,992.71 20,221.61; 85,763.81
3 Tx Naïve All Patients SOF RBV 24 wk. vs PEG RBV 24 wk 2 $97,028.01 45,661.88; 148,394.14
3 Tx Naïve With Cirrhosis SOF RBV 24 wk. vs PEG RBV 24 wk 2 $28,155.70 15,997.15; 40,314.25
3 Tx Naïve Without Cirrhosis SOF RBV 24 wk. vs PEG RBV 24 wk 2 $200,289.75 94,317.94; 306,261.56
3 Tx Experienced All Patients SOF RBV 24 wk. vs PEG RBV 48 wk 2 $108,643.85 9097.03; 208,190.67
1 Tx Experienced All Patients SOF PEG RBV 12 wk. vs BOC PEG RBV 48 wk 1 $42,691.76 NA
1 Tx Experienced Without Cirrhosis SOF PEG RBV 12 wk. vs BOC PEG RBV 48 wk 1 $20,556.36 NA
1 Tx Experienced All Patients SOF PEG RBV 12 wk. vs No Tx 1 $16,636.38 NA
1 Tx Naïve All Patients SOF PEG RBV 12 wk. vs No Tx 1 $6183.71 NA
1 Tx Naïve With Cirrhosis SOF PEG RBV 12 wk. vs No Tx 1 $17,319.03 NA
1 Tx Naïve Without Cirrhosis SOF PEG RBV 12 wk. vs No Tx 1 $2075.11 NA
1 Tx Experienced Without Cirrhosis SOF PEG RBV 12 wk. vs PEG RBV 48 wk 1 $28,230.10 NA
1 Tx Naïve Without Cirrhosis SOF PEG RBV 12 wk. vs PEG RBV 48 wk 1 $27,395.56 NA
1 Tx Experienced All Patients SOF PEG RBV 12 wk. vs TEL PEG RBV 48 wk 1 $81,887.61 NA
1 Tx Experienced With Cirrhosis SOF PEG RBV 12 wk. vs TEL PEG RBV 48 wk 1 $30,799.23 NA
1 Tx Experienced Without Cirrhosis SOF PEG RBV 12 wk. vs TEL PEG RBV 48 wk 1 $22,125.61 NA
1 Tx Naïve With Cirrhosis SOF PEG RBV 12 wk. vs TEL PEG RBV 48 wk 1 $24,022.23 NA
1 Tx Naïve Without Cirrhosis SOF RBV 24 wk. vs No Tx 1 $74,046.69 NA
1 Tx Naïve All Patients SOF RBV 24 wk. vs PEG RBV 48 wk 1 $203,337.60 NA
2 Tx Naïve With Cirrhosis SOF PEG RBV 12 wk. vs PEG RBV 24 wk 1 $36,118.69 NA
2 Tx Naïve Without Cirrhosis SOF PEG RBV 12 wk. vs PEG RBV 24 wk 1 $242,147.86 NA
2 Tx Experienced Without Cirrhosis SOF RBV 12 wk. vs No Tx 1 $64,437.10 NA
2 Tx Naïve Without Cirrhosis SOF RBV 12 wk. vs PEG RBV 24 wk 1 $89,048.45 NA
2 Tx Experienced With Cirrhosis SOF RBV 12 wk. vs PEG RBV 48 wk 1 $18,783.93 NA
3 Tx Experienced With Cirrhosis SOF PEG RBV 12 wk. vs No Tx 1 $12,001.35 NA
3 Tx Experienced With Cirrhosis SOF PEG RBV 12 wk. vs PEG RBV 48 wk 1 $3389.07 NA
3 Tx Experienced Without Cirrhosis SOF PEG RBV 12 wk. vs PEG RBV 48 wk 1 $19,301.90 NA
3 Tx Experienced With Cirrhosis SOF RBV 12 wk. vs No Tx 1 $75,409.37 NA
3 Tx Experienced Without Cirrhosis SOF RBV 12 wk. vs No Tx 1 $186,528.47 NA
3 Tx Naïve With Cirrhosis SOF RBV 12 wk. vs No Tx 1 $39,799.39 NA
3 Tx Naïve Without Cirrhosis SOF RBV 12 wk. vs No Tx 1 $58,784.73 NA
3 Tx Naïve With Cirrhosis SOF RBV 12 wk. vs PEG RBV 24 wk 1 $189,241.61 NA
3 Tx Experienced With Cirrhosis SOF RBV 24 wk. vs PEG RBV 48 wk 1 $70,111.60 NA
3 Tx Experienced Without Cirrhosis SOF RBV 24 wk. vs PEG RBV 48 wk 1 $58,828.37 NA
  1. Key: BOC = boceprevir; NA = not applicable, PEG = pegylated interferon, RBV = ribavirin, SOF = sofosbuvir; Tx = treatment, vs = versus, wk. = week, 95% CI, 95% confidence interval “lower bound; upper bound”
  2. Based on data reported in included intervention models: Cure 2015a [28], Cure 2015b [29], Linas, 2015 [37], Liu 2014 [39], Najafzadeh 2015 [41], San Miguel 2015 [47], Saab 2014 [46]