Table 6 Synthesis of ICERs from the included intervention studies when available with more than one comparison

1

Tx Naïve

All Patients

SOF PEG RBV 12 wk. vs BOC PEG RBV 48 wk

5

$18,499.62

6871.38; 30,127.86

1

Tx Naïve

All Patients

SOF PEG RBV 12 wk. vs PEG RBV 48 wk

5

$26,460.59

18,342.69; 34,578.49

2

Tx Naïve

All Patients

SOF RBV 12 wk. vs PEG RBV 24 wk

5

$88,099.60

68,301.59; 107,897.61

3

Tx Naïve

All Patients

SOF PEG RBV 12 wk. vs PEG RBV 24 wk

4

$41,080.16

28,962.61; 53,197.71

3

Tx Experienced

All Patients

SOF PEG RBV 12 wk. vs PEG RBV 48 wk

4

$29,092.09

9276.64; 48,907.54

1

Tx Naïve

All Patients

SOF PEG RBV 12 wk. vs TEL PEG RBV 48 wk

3

$25,954.71

− 242.37; 52,151.79

1

Tx Naïve

All Patients

SOF RBV 24 wk. vs No Tx

3

$61,607.34

43,706.46; 79,508.22

2

Tx Naïve

All Patients

SOF RBV 12 wk. vs No Tx

3

$13,411.94

6648.19; 20,175.69

2

Tx Experienced

All Patients

SOF RBV 12 wk. vs PEG RBV 48 wk

3

$38,521.07

8866.40; 68,175.74

3

Tx Naïve

With Cirrhosis

SOF PEG RBV 12 wk. vs PEG RBV 24 wk

3

$15,496.88

5997.08; 24,996.68

3

Tx Experienced

All Patients

SOF RBV 24 wk. vs No Tx

3

$34,349.09

23,903.12; 44,795.06

3

Tx Experienced

With Cirrhosis

SOF RBV 24 wk. vs No Tx

3

$61,199.47

−11,419.99; 133,818.93

3

Tx Naïve

All Patients

SOF RBV 24 wk. vs No Tx

3

$26,708.10

20,272.80; 33,143.40

3

Tx Naïve

With Cirrhosis

SOF RBV 24 wk. vs No Tx

3

$16,688.78

5501.36; 27,876.20

1

Tx Experienced

With Cirrhosis

SOF PEG RBV 12 wk. vs BOC PEG RBV 48 wk

2

$8155.21

− 6369.20; 22,679.62

1

Tx Naïve

With Cirrhosis

SOF PEG RBV 12 wk. vs BOC PEG RBV 48 wk

2

$14,343.01

2811.59; 25,874.43

1

Tx Experienced

All Patients

SOF PEG RBV 12 wk. vs PEG RBV 48 wk

2

$16,338.76

− 9294.13; 41,971.65

1

Tx Experienced

With Cirrhosis

SOF PEG RBV 12 wk. vs PEG RBV 48 wk

2

$9308.71

− 6564.02; 25,181.44

1

Tx Naïve

With Cirrhosis

SOF PEG RBV 12 wk. vs PEG RBV 48 wk

2

$14,480.59

10,944.65; 18,016.53

1

Tx Naïve

With Cirrhosis

SOF RBV 24 wk. vs No Tx

2

$45,242.13

19,014.80; 71,469.46

2

Tx Experienced

All Patients

SOF RBV 12 wk. vs No Tx

2

$16,839.10

13,661.57; 20,016.63

2

Tx Experienced

With Cirrhosis

SOF RBV 12 wk. vs No Tx

2

$20,559.84

5250.75; 35,868.93

2

Tx Naïve

With Cirrhosis

SOF RBV 12 wk. vs No Tx

2

$12,953.61

3499.67; 22,407.55

2

Tx Naïve

Without Cirrhosis

SOF RBV 12 wk. vs No Tx

2

$31,518.88

− 3263.39; 66,301.15

2

Tx Naïve

With Cirrhosis

SOF RBV 12 wk. vs PEG RBV 24 wk

2

$33,523.44

21,330.96; 45,715.92

3

Tx Experienced

All Patients

SOF PEG RBV 12 wk. vs No Tx

2

$16,543.85

9323.35; 23,764.35

3

Tx Naïve

Without Cirrhosis

SOF PEG RBV 12 wk. vs PEG RBV 24 wk

2

$162,539.68

−43,346.34; 368,425.70

3

Tx Experienced

Without Cirrhosis

SOF RBV 24 wk. vs No Tx

2

$87,973.28

− 4537.35; 180,483.91

3

Tx Naïve

Without Cirrhosis

SOF RBV 24 wk. vs No Tx

2

$52,992.71

20,221.61; 85,763.81

3

Tx Naïve

All Patients

SOF RBV 24 wk. vs PEG RBV 24 wk

2

$97,028.01

45,661.88; 148,394.14

3

Tx Naïve

With Cirrhosis

SOF RBV 24 wk. vs PEG RBV 24 wk

2

$28,155.70

15,997.15; 40,314.25

3

Tx Naïve

Without Cirrhosis

SOF RBV 24 wk. vs PEG RBV 24 wk

2

$200,289.75

94,317.94; 306,261.56

3

Tx Experienced

All Patients

SOF RBV 24 wk. vs PEG RBV 48 wk

2

$108,643.85

9097.03; 208,190.67

1

Tx Experienced

All Patients

SOF PEG RBV 12 wk. vs BOC PEG RBV 48 wk

1

$42,691.76

NA

1

Tx Experienced

Without Cirrhosis

SOF PEG RBV 12 wk. vs BOC PEG RBV 48 wk

1

$20,556.36

NA

1

Tx Experienced

All Patients

SOF PEG RBV 12 wk. vs No Tx

1

$16,636.38

NA

1

Tx Naïve

All Patients

SOF PEG RBV 12 wk. vs No Tx

1

$6183.71

NA

1

Tx Naïve

With Cirrhosis

SOF PEG RBV 12 wk. vs No Tx

1

$17,319.03

NA

1

Tx Naïve

Without Cirrhosis

SOF PEG RBV 12 wk. vs No Tx

1

$2075.11

NA

1

Tx Experienced

Without Cirrhosis

SOF PEG RBV 12 wk. vs PEG RBV 48 wk

1

$28,230.10

NA

1

Tx Naïve

Without Cirrhosis

SOF PEG RBV 12 wk. vs PEG RBV 48 wk

1

$27,395.56

NA

1

Tx Experienced

All Patients

SOF PEG RBV 12 wk. vs TEL PEG RBV 48 wk

1

$81,887.61

NA

1

Tx Experienced

With Cirrhosis

SOF PEG RBV 12 wk. vs TEL PEG RBV 48 wk

1

$30,799.23

NA

1

Tx Experienced

Without Cirrhosis

SOF PEG RBV 12 wk. vs TEL PEG RBV 48 wk

1

$22,125.61

NA

1

Tx Naïve

With Cirrhosis

SOF PEG RBV 12 wk. vs TEL PEG RBV 48 wk

1

$24,022.23

NA

1

Tx Naïve

Without Cirrhosis

SOF RBV 24 wk. vs No Tx

1

$74,046.69

NA

1

Tx Naïve

All Patients

SOF RBV 24 wk. vs PEG RBV 48 wk

1

$203,337.60

NA

2

Tx Naïve

With Cirrhosis

SOF PEG RBV 12 wk. vs PEG RBV 24 wk

1

$36,118.69

NA

2

Tx Naïve

Without Cirrhosis

SOF PEG RBV 12 wk. vs PEG RBV 24 wk

1

$242,147.86

NA

2

Tx Experienced

Without Cirrhosis

SOF RBV 12 wk. vs No Tx

1

$64,437.10

NA

2

Tx Naïve

Without Cirrhosis

SOF RBV 12 wk. vs PEG RBV 24 wk

1

$89,048.45

NA

2

Tx Experienced

With Cirrhosis

SOF RBV 12 wk. vs PEG RBV 48 wk

1

$18,783.93

NA

3

Tx Experienced

With Cirrhosis

SOF PEG RBV 12 wk. vs No Tx

1

$12,001.35

NA

3

Tx Experienced

With Cirrhosis

SOF PEG RBV 12 wk. vs PEG RBV 48 wk

1

$3389.07

NA

3

Tx Experienced

Without Cirrhosis

SOF PEG RBV 12 wk. vs PEG RBV 48 wk

1

$19,301.90

NA

3

Tx Experienced

With Cirrhosis

SOF RBV 12 wk. vs No Tx

1

$75,409.37

NA

3

Tx Experienced

Without Cirrhosis

SOF RBV 12 wk. vs No Tx

1

$186,528.47

NA

3

Tx Naïve

With Cirrhosis

SOF RBV 12 wk. vs No Tx

1

$39,799.39

NA

3

Tx Naïve

Without Cirrhosis

SOF RBV 12 wk. vs No Tx

1

$58,784.73

NA

3

Tx Naïve

With Cirrhosis

SOF RBV 12 wk. vs PEG RBV 24 wk

1

$189,241.61

NA

3

Tx Experienced

With Cirrhosis

SOF RBV 24 wk. vs PEG RBV 48 wk

1

$70,111.60

NA

3

Tx Experienced

Without Cirrhosis

SOF RBV 24 wk. vs PEG RBV 48 wk

1

$58,828.37

NA