Assessment of research waste part 1: an exemplar from examining study design, surrogate and clinical endpoints in studies of calcium intake and vitamin D supplementation

Table 2 Publications of calcium intake with non-skeletal endpoints by study design

Abbreviation: IHD/MI ischaemic heart disease or myocardial infarction, RCT randomised controlled trial
^aTwo RCTs had colorectal adenoma as the primary endpoint. All other RCTs reported data as secondary endpoints
^bUnpublished data for myocardial infarction and stroke from an additional 11 RCTs published in meta-analyses [25, 26]
^cUnpublished data for cancer published in a meta-analysis [27] from an additional 6 RCTs for total cancer and colorectal cancer, 4 RCTs for breast cancer, and 2 RCTs for prostate cancer

ISSN: 1471-2288