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Table 1 Cost-effectiveness probability, EVPIn, and expected gain for an additional inclusion according to total sample size (n)

From: A new approach for sample size calculation in cost-effectiveness studies based on value of information

Total Sample size (n)

Cost-effectiveness probability (%)

EVPIn (€)

EVPI decreasing for an additional inclusion in each group (€)

Expected gain for an additional inclusion in each groupa (€)

100

94,51

10,365,256

480,869

+ 476,355

200

98,81

1,289,276

47,695

+ 43,181

300

99,72

216,451

7248

+ 2734

328

99,81

135,950

4434

−81

400

99,93

41,514

1312

− 3203

500

99,98

8595

262

− 4253

600

99,99

1816

55

− 4460

  1. a The monetary gain for an additional inclusion in each group (i.e. 2 participants in this example) is the difference between the EVPIn decrement and the costs induced by the inclusion and follow-up of two additional participants in the study (2257.25 €/participant in this example)