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Table 2 Parameters needed for a sample size calculation method based on a test statistic and resulting sample size per group with the method proposed by Glick

From: A new approach for sample size calculation in cost-effectiveness studies based on value of information

Study

Difference in mean costs (€)

Difference in mean effectiveness

Ceiling cost-effectiveness ratio

Standard deviation of costs (€)

Standard deviation of effectiveness

Coefficient of correlation between the difference in costs and the difference in effectiveness

Sample size per group through the method proposed by Glick a

(∆C)

(∆E)

(λ)

(σC)

(σE)

(ρ)

FEMCAT

312

0,07

16,750 € /complication avoided

100

0,41

0

1000

INTACT

− 725

0,075

20,000 € /QALY

800

0,24

0

75

OXYNAT

17,6

0,00048

100,000 € /complication avoided

1008

0,00078

0

17,350

  1. QALY quality-adjusted life year
  2. awith a 80% power and a 5% alpha risk