Table 2 Bayesian estimates of pk’s via NCRM under scenario 1
From: A nonparametric Bayesian continual reassessment method in single-agent dose-finding studies
True | 0.05 | 0.08 | 0.12 | 0.20 | 0.30 | 0.45 | 0.60 | 0.70 | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
i | x i | y i1 | y i2 | y i3 | \(\hat {p}_{1}\) | \(\hat {p}_{2}\) | \(\hat {p}_{3}\) | \(\hat {p}_{4}\) | \(\hat {p}_{5}\) | \(\hat {p}_{6}\) | \(\hat {p}_{7}\) | \(\hat {p}_{8}\) |
1 | d 1 | 0 | 0 | 1 | ||||||||
2 | d 1 | 0 | 0 | 0 | 0.0156 | - | - | - | - | - | - | - |
3 | d 2 | 0 | 0 | 0 | 0.0278 | 0.0380 | - | - | - | - | - | - |
4 | d 3 | 1 | 0 | 0 | 0.0439 | 0.0573 | 0.0789 | - | - | - | - | - |
5 | d 4 | 0 | 0 | 0 | 0.0501 | 0.0703 | 0.1014 | 0.1336 | - | - | - | - |
6 | d 5 | 0 | 0 | 0 | 0.0585 | 0.0809 | 0.1169 | 0.1534 | 0.2109 | - | - | - |
7 | d 6 | 0 | 0 | 1 | 0.0589 | 0.0852 | 0.1248 | 0.1682 | 0.2377 | 0.3426 | - | - |
8 | d 5 | 0 | 1 | 0 | 0.0595 | 0.0734 | 0.1196 | 0.1672 | 0.2430 | 0.3457 | - | - |
9 | d 6 | 1 | 1 | 1 | 0.0711 | 0.1018 | 0.1496 | 0.2006 | 0.2841 | 0.4060 | - | - |
10 | d 5 | 0 | 1 | 0 | 0.0763 | 0.0954 | 0.1484 | 0.2023 | 0.2864 | 0.4063 | - | - |
11 | d 5 | 0 | 1 | 1 | 0.0681 | 0.0995 | 0.1528 | 0.2112 | 0.3116 | 0.4156 | - | - |
12 | d 5 | 0 | 0 | 1 | 0.0814 | 0.1144 | 0.1668 | 0.2227 | 0.3190 | 0.4196 | - | - |
13 | d 4 | 0 | 0 | 0 | 0.0702 | 0.0979 | 0.1474 | 0.1965 | 0.3072 | 0.4144 | - | - |
14 | d 5 | 0 | 0 | 1 | 0.0670 | 0.0979 | 0.1431 | 0.1958 | 0.3104 | 0.4151 | - | - |
15 | d 5 | 0 | 0 | 0 | 0.0672 | 0.0960 | 0.1421 | 0.1915 | 0.2904 | 0.4062 | - | - |
16 | d 5 | 0 | 0 | 1 | 0.0767 | 0.1073 | 0.1549 | 0.2026 | 0.2989 | 0.4094 | - | - |
17 | d 5 | 0 | 1 | 0 | 0.0704 | 0.1004 | 0.1450 | 0.1941 | 0.2958 | 0.4070 | - | - |
18 | d 5 | 1 | 1 | 0 | 0.0723 | 0.1039 | 0.1546 | 0.2066 | 0.3196 | 0.4205 | - | - |
19 | d 4 | 0 | 0 | 0 | 0.0632 | 0.0916 | 0.1369 | 0.1842 | 0.3128 | 0.4170 | - | - |
20 | d 5 | 0 | 0 | 0 | 0.0730 | 0.1046 | 0.1428 | 0.1868 | 0.2977 | 0.4103 | - | - |