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Table 3 Selection probabilities and total numbers of toxicities observed for logistic model, power model and NCRM under six scenarios

From: A nonparametric Bayesian continual reassessment method in single-agent dose-finding studies

   Dose level # of # of
Scenario Method 1 2 3 4 5 6 7 8 Tox. Pat.
1 Logistic 0.000 0.000 0.008 0.227 0.637 0.128 0.000 0.000 15 60
  Power 0.000 0.000 0.004 0.212 0.664 0.120 0.000 0.000 15 60
  NCRM5a 0.000 0.002 0.001 0.161 0.773 0.063 0.000 0.000 15 60
  NCRM2a 0.000 0.000 0.000 0.007 0.980 0.013 0.000 0.000 16 60
2 Logistic 0.000 0.001 0.042 0.362 0.571 0.024 0.000 0.000 13 60
  Power 0.000 0.001 0.028 0.369 0.581 0.021 0.000 0.000 14 60
  NCRM5 0.002 0.000 0.005 0.292 0.698 0.003 0.000 0.000 15 60
  NCRM2 0.000 0.000 0.000 0.186 0.814 0.000 0.000 0.000 14 60
3 Logistic 0.000 0.000 0.000 0.002 0.043 0.108 0.306 0.541 13 60
  Power 0.000 0.000 0.000 0.001 0.031 0.104 0.311 0.553 13 60
  NCRM5 0.000 0.001 0.007 0.019 0.028 0.117 0.373 0.455 13 60
  NCRM2 0.000 0.000 0.000 0.000 0.000 0.008 0.379 0.613 13 60
4 Logistic 0.000 0.000 0.000 0.002 0.036 0.143 0.286 0.533 11 60
  Power 0.000 0.000 0.000 0.000 0.028 0.128 0.321 0.523 11 60
  NCRM5 0.000 0.001 0.003 0.007 0.011 0.086 0.289 0.603 12 60
  NCRM2 0.000 0.000 0.000 0.000 0.000 0.004 0.263 0.733 12 60
5 Logistic 0.804 0.189 0.007 0.000 0.000 0.000 0.000 0.000 20 60
  Power 0.811 0.183 0.006 0.000 0.000 0.000 0.000 0.000 20 60
  NCRM5 0.898 0.100 0.002 0.000 0.000 0.000 0.000 0.000 19 60
  NCRM2 0.971 0.029 0.000 0.000 0.000 0.000 0.000 0.000 19 60
6 Logistic 0.970 0.027 0.003 0.000 0.000 0.000 0.000 0.000 24 60
  Power 0.972 0.028 0.000 0.000 0.000 0.000 0.000 0.000 24 60
  NCRM5 0.987 0.013 0.000 0.000 0.000 0.000 0.000 0.000 24 60
  NCRM2 1.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 24 60
  1. aNCRM5 and NCRM2 denote NCRM method with α=5 and 20, respectively