Table 3 Selection probabilities and total numbers of toxicities observed for logistic model, power model and NCRM under six scenarios
From: A nonparametric Bayesian continual reassessment method in single-agent dose-finding studies
Dose level | # of | # of | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Scenario | Method | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | Tox. | Pat. |
1 | Logistic | 0.000 | 0.000 | 0.008 | 0.227 | 0.637 | 0.128 | 0.000 | 0.000 | 15 | 60 |
Power | 0.000 | 0.000 | 0.004 | 0.212 | 0.664 | 0.120 | 0.000 | 0.000 | 15 | 60 | |
NCRM5a | 0.000 | 0.002 | 0.001 | 0.161 | 0.773 | 0.063 | 0.000 | 0.000 | 15 | 60 | |
NCRM2a | 0.000 | 0.000 | 0.000 | 0.007 | 0.980 | 0.013 | 0.000 | 0.000 | 16 | 60 | |
2 | Logistic | 0.000 | 0.001 | 0.042 | 0.362 | 0.571 | 0.024 | 0.000 | 0.000 | 13 | 60 |
Power | 0.000 | 0.001 | 0.028 | 0.369 | 0.581 | 0.021 | 0.000 | 0.000 | 14 | 60 | |
NCRM5 | 0.002 | 0.000 | 0.005 | 0.292 | 0.698 | 0.003 | 0.000 | 0.000 | 15 | 60 | |
NCRM2 | 0.000 | 0.000 | 0.000 | 0.186 | 0.814 | 0.000 | 0.000 | 0.000 | 14 | 60 | |
3 | Logistic | 0.000 | 0.000 | 0.000 | 0.002 | 0.043 | 0.108 | 0.306 | 0.541 | 13 | 60 |
Power | 0.000 | 0.000 | 0.000 | 0.001 | 0.031 | 0.104 | 0.311 | 0.553 | 13 | 60 | |
NCRM5 | 0.000 | 0.001 | 0.007 | 0.019 | 0.028 | 0.117 | 0.373 | 0.455 | 13 | 60 | |
NCRM2 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.008 | 0.379 | 0.613 | 13 | 60 | |
4 | Logistic | 0.000 | 0.000 | 0.000 | 0.002 | 0.036 | 0.143 | 0.286 | 0.533 | 11 | 60 |
Power | 0.000 | 0.000 | 0.000 | 0.000 | 0.028 | 0.128 | 0.321 | 0.523 | 11 | 60 | |
NCRM5 | 0.000 | 0.001 | 0.003 | 0.007 | 0.011 | 0.086 | 0.289 | 0.603 | 12 | 60 | |
NCRM2 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.004 | 0.263 | 0.733 | 12 | 60 | |
5 | Logistic | 0.804 | 0.189 | 0.007 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 20 | 60 |
Power | 0.811 | 0.183 | 0.006 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 20 | 60 | |
NCRM5 | 0.898 | 0.100 | 0.002 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 19 | 60 | |
NCRM2 | 0.971 | 0.029 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 19 | 60 | |
6 | Logistic | 0.970 | 0.027 | 0.003 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 24 | 60 |
Power | 0.972 | 0.028 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 24 | 60 | |
NCRM5 | 0.987 | 0.013 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 24 | 60 | |
NCRM2 | 1.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 0.000 | 24 | 60 | |