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Table 4 Average numbers of patients treated at each of eights doses for logistic model, power model and NCRM

From: A nonparametric Bayesian continual reassessment method in single-agent dose-finding studies

   Dose level
Scenario Method 1 2 3 4 5 6 7 8
1 Logistic 3.579 4.008 5.916 14.463 23.304 8.124 0.576 0.030
  Power 3.489 3.954 5.622 14.739 23.889 7.755 0.543 0.009
  NCRM5a 3.474 3.615 3.912 15.462 27.387 6.009 0.141 0.000
  NCRM2a 3.423 3.558 3.708 8.298 35.454 5.493 0.066 0.000
2 Logistic 3.582 4.632 8.868 19.206 21.147 2.535 0.030 0.000
  Power 3.486 4.158 8.004 20.496 21.663 2.178 0.015 0.000
  NCRM5 3.447 3.648 4.569 18.543 25.698 4.065 0.300 0.000
  NCRM2 3.447 3.513 3.693 19.977 27.825 1.497 0.048 0.000
3 Logistic 3.108 3.486 4.137 5.274 6.882 9.096 11.724 16.293
  Power 3.066 3.480 4.089 5.157 6.552 8.970 12.342 16.344
  NCRM5 3.090 3.435 3.684 3.897 4.908 8.901 17.457 14.628
  NCRM2 3.057 3.420 3.660 3.636 3.531 3.930 21.168 17.598
4 Logistic 3.105 3.483 3.942 4.977 7.266 10.125 11.610 15.492
  Power 3.066 3.468 3.843 4.737 6.573 10.266 12.861 15.186
  NCRM5 3.135 3.366 3.453 3.777 4.395 7.809 16.281 17.784
  NCRM2 3.084 3.387 3.573 3.612 3.522 3.630 18.879 20.313
5 Logistic 44.637 12.972 2.229 0.156 0.006 0.000 0.000 0.000
  Power 45.189 12.822 1.848 0.135 0.006 0.000 0.000 0.000
  NCRM5 49.740 8.958 1.176 0.114 0.012 0.000 0.000 0.000
  NCRM2 53.178 6.366 0.408 0.042 0.006 0.000 0.000 0.000
6 Logistic 54.468 4.467 0.894 0.141 0.030 0.000 0.000 0.000
  Power 54.573 4.500 0.810 0.102 0.015 0.000 0.000 0.000
  NCRM5 57.676 2.865 0.414 0.039 0.006 0.000 0.000 0.000
  NCRM2 58.149 1.596 0.237 0.018 0.000 0.000 0.000 0.000
  1. aNCRM5 and NCRM2 denote NCRM method with α=5 and 20, respectively