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Table 2 summary description of the tool development process and risk of bias

From: Prognostic models for intracerebral hemorrhage: systematic review and meta-analysis

Author Source of data Sampling reported Nr patients Nr events Nr variable EPV Loss to follow-up: Missing data reported? Blinding reported? Modelling method Internal validation Calibration
Alsina [24] Cohort Not reported 100 38 3 12.7 0% Yes No Logistic No Hosmer-Lemeshow
Berwaerts [41] Cohort Consecutive 42 18 2 9 0% Yes No Logistic No Not reported
Bhatia [65] Cohort Consecutive 214 70 4 17.5 0% No No Logistic No Not reported
Broderick [44] Cohort Consecutive 162 83 2 19.8 0.6% Yes No Logistic No Not reported
Broderick´ [44] Cohort Consecutive 162 83 4 39.5 0.6% Yes No Logistic No Not reported
Celik [68] Cohort Not reported 257 119 12 9.9 0% No No ANN Cross-validation Not reported
Cerillo [21] Cohort Not reported 88 34 7 4.9 0% No No Univariate analysis No Not reported
Chen [45] Cohort Consecutive 285 61 4 15.3 0% No No Logistic No Not reported
Chiu [61] Cohort Not reported 106 16 2 8 0% Yes No CART + SVM Split sample Not reported
Chuang [63] Cohort Not reported 293 40 5 8 0% No No Logistic Cross-validation Hosmer-Lemeshow
Edwards [28] Cohort Consecutive 81 21 15 1.4 0% No No ANN No Hosmer-Lemeshow
Edwards´ [28] Cohort Consecutive 81 21 4 5.3 0% Yes No Logistic No Hosmer-Lemeshow
Fogelholm [31] Cohort Consecutive 282 120 6 20 0% Yes No Logistic No Not reported
Frithz [12] Cohort Not reported 91 79 2 6 0% Yes No CART No Not reported
Galbois [38] Cohort Consecutive 72 35 2 17.5 0% Yes No Logistic Cross-validation Not reported
Galbois´ [38] Cohort Consecutive 72 35 2 17.5 0% Yes No Logistic Cross-validation Not reported
Grellier [66] Cohort Not reported 300 Not reported 9 n/a 0% No No Unclear No Not reported
Hallevi [34] Cohort Consecutive 174 Not reported 2 n/a 0% Yes No Logistic No Not reported
Hemphill [48] Cohort Consecutive 152 68 5 13.6 0% Yes No Logistic No Not reported
Ho [64] Registry Consecutive 805 164 6 27.3 0% No No Logistic No Le Cessie and Howelingen + plots
Huang [40] Cohort Consecutive 107 72 3 11.7 0% Yes No Logistic No Not reported
Li [50] Cohort Consecutive 227 49 4 12.3 0% Yes No Logistic No Not reported
Li´ [49] Cohort Consecutive 716 140 4 35 0% Yes No Logistic No Not reported
Lukic [33] Cohort Consecutive 411 256 5 31 0% Yes No Logistic No Hosmer-Lemeshow
Lukic´ [26] Case-Control Not reported 200 100 8 12.5 0% Yes No ANN Split Sample Not reported
Lukic´´ [26] Case-Control Not reported 200 100 2 50 0% Yes No Logistic No Not reported
Masé [27] Cohort Consecutive 138 38 3 12.7 0% No No Logistic No Not reported
Parry-Jones [53] Cohort Consecutive 1175 483 4 120.8 1.1% Yes No Logistic No Not reported
Peng [54] Cohort Not reported 423 62 20 3.1 0% Yes No Random Forrest Cross-validation Not reported
Peng´ [54] Cohort Not reported 423 62 10 6.2 0% Yes No ANN Cross-validation Not reported
Peng´´ [54] Cohort Not reported 423 62 10 12.4 0% Yes No SVM Cross-validation Not reported
Peng´´´ [54] Cohort Not reported 423 62 5 12.4 0% Yes No Logistic Cross-validation Not reported
Romano [56] Cohort Consecutive 154 63 3 21 0.6% Yes No Logistic Split sample Not reported
Ruiz-Sandoval [58] Cohort Consecutive 378 174 5 34.8 0% Yes No Logistic Bootstrap Hosmer-Lemeshow
Safatli [60] Cohort Consecutive 342 86 3 28.7 0% No No Logistic No Hosmer-Lemeshow
Szepesi [32] Cohort Not reported 125 59 6 9.8 0% Yes No Logistic No Hosmer-Lemeshow
Tabak [59] Administrative data Consecutive 29,975 6765 17 397.9 0% Yes No Logistic Bootstrap Calibration plot
Takahashi [67] Cohort Not reported 347 70 3 23.3 0% No No CART Cross-validation Not reported
Takahashi´ [67] Cohort Not reported 347 70 4 17.5 0% No No Logistic No Not reported
Tshikwela [36] Cohort Not reported 185 68 3 22.7 0% No No Logistic No Not reported
Tshikwela´ [36] Cohort Not reported 185 68 3 22.7 0% No No Logistic No Not reported
Tuhrim [23] Cohort Not reported 129 27 5 5.4 0% No No Logistic No Not reported
Tuhrim´ [30] Registry Not reported 187 54 5 10.8 2.1% Yes No Logistic No Not reported
Tuhrim´´ [29] Registry Not reported 73 25 3 8.3 0% Yes No Logistic No Not reported
Ziai [35] Cohort Consecutive 170 87 4 20.8 0% Yes No Logistic Cross-validation Not reported
Zis [39] Cohort Consecutive 191 61 5 12.2 0% No No Logistic No Hosmer-Lemeshow
Appelboom [10] Cohort Consecutive 84 18 5 3.6 Unclear Yes Yes Logistic (Update) No Not reported
Creutzfeld [47] Cohort Consecutive 424 187 7 26.7 0% No No Logistic No Hosmer-Lemeshow
Flemming [18] Cohort Consecutive 81 24 2 12 0% Yes No Decision Tree No Not reported
Flemming´ [18] Cohort Consecutive 81 51 3 10 0% Yes No Decision Tree No Not reported
Hallevy [25] Cohort Consecutive 184 70 6 11.7 0% No No Logistic No Not reported
Ji [51] Registry Consecutive 1953 912 7 130.3 12.6% Yes Yes Logistic Split sample Hosmer-Lemeshow
Lisk [22] Cohort Consecutive 75 35 4 8.8 0% Yes No Logistic No Hosmer-Lemeshow
Lisk´ [22] Cohort Consecutive 42 9 3 3 0% Yes No Logistic No Hosmer-Lemeshow
Neidert [11] Cohort Consecutive 67 28 8 3.5 0% No No Univariate analysis No Not reported
Misra [15] Cohort Not reported 38 Not reported 4 n/a Unclear Yes No Logistic No Not reported
Mittal [52] Cohort Consecutive 92 62 5 6 0% No Yes Logistic (update) No Not reported
Portenoy [20] Cohort Consecutive 112 41 3 13.7 0% No No Logistic No Hosmer-Lemeshow
Poungvarin [55] Cohort Consecutive 995 402 4 100.5 0% Yes No Logistic No Not reported
Rost [57] Cohort Consecutive 418 121 5 24.2 13.4% Yes No Logistic Split sample Not reported
Shah [17] Cohort Not reported 53 29 2 12 0% No No Logistic No Not reported
Shaya [19] Cohort Consecutive 50 n/a 3 n/a 0% No No Ordered logistic No Not reported
Weimar [42] RCTs Not reported 564 171 3 57 0% Yes No Logistic (update) No Calibration plot
Weimar´ [37] Cohort Consecutive 207 78 2 39 20.4% Yes Yes Logistic No Not reported
Weimar´´ [43] Registry Consecutive 340 89 3 29.7 27% Yes Yes Logistic (update) No Not reported
Cheung [46] Cohort Consecutive 141 31a 5 6.2a 0.7% Yes No Logistic No Not reported
49b 9.8b
Cheung´ [46] Cohort Consecutive 141 31a 5 6.2a 0.7% Yes No Logistic (update) No Not reported
49b 9.8b
Cho [14] RCT Consecutive 226 42a 3 14a 0% Yes No Logistic No Not reported
Unclearb n/ab
Godoy [62] Cohort Consecutive 153 53a 5 10.6a 0% Yes No Logistic (update) No Not reported
59b 11.8b
Godoy´ [62] Cohort Consecutive 153 53a 5 10.6a 0% Yes No Logistic (update) No Not reported
59b 11.8b
Lei [13] Cohort Consecutive 170 43a 4 10.8a 0% No Yes Logistic Split sample Not reported
90b 20b
Stein [16] Cohort Consecutive 110 31a 4 7.8a 0% Yes No Logistic Split sample Not reported
86b 4.5b
  1. ANN artificial neural networks, CART classification and regression tree, SVM support vector machine
  2. aValues relating to mortality
  3. bValues relating to functional outcome