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Table 2 Certainty of evidence

From: Methods for trustworthy nutritional recommendations NutriRECS (Nutritional Recommendations and accessible Evidence summaries Composed of Systematic reviews): a protocol

GRADEDefinition
HighWe are very confident that the true effect lies close to that of the estimate of the effect
ModerateWe are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different
LowOur confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect
Very LowWe have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect
  1. Although certainty of evidence is a continuum; GRADE’s discrete categorisation involves some degree of arbitrariness. Nevertheless, advantages of simplicity, transparency, and vividness outweigh these limitations