|
Months on effective regimen (mean, sd)
|
11.6 (7.9)
|
|
Ever on effective regimen
|
369 (82.6)
|
|
Sociodemographic characteristics
|
|
Age, years (mean, sd)
|
35.9 (11.4)
|
|
Female sex
|
84 (18.8)
|
|
Married (n = 434)
|
200 (46.1)
|
|
Unemployed (n = 445)
|
352 (79.1)
|
|
Current or previous incarceration
|
237 (53.0)
|
|
Alcohol abuse/dependence
|
194 (43.4)
|
|
Illicit drug use
|
79 (17.7)
|
|
Homelessness
|
16 (3.6)
|
|
Comorbidities
|
|
HIV-positive (n = 446)
|
3 (0.7)
|
|
Diabetes mellitus (n = 446)
|
18 (4.0)
|
|
Comorbid condition
|
322 (72.0)
|
|
Prior TB treatment exposure
|
|
Previously treated for TB
|
444 (99.3)
|
|
History of prior injectable exposure (n = 436)
|
145 (33.3)
|
|
History of prior fluoroquinolone exposure (n = 436)
|
69 (15.8)
|
|
History of prior default
|
16 (3.6)
|
|
Number of previous TB treatments (mean, sd)
|
2.1 (1.2)
|
|
> 2 previous TB treatment (n = 436)
|
141 (32.3)
|
|
Clinical indications of disease severity
|
|
Bilateral and cavitary disease on baseline chest x-ray (n = 443)
|
278 (62.8)
|
|
Severe pulmonary disease on baseline chest x-ray
|
195 (43.6)
|
|
Low BMI at start of treatment (n = 446)
|
190 (42.6)
|
|
Severe baseline clinical status
|
277 (62.0)
|
|
Extrapulmonary disease (n = 381)
|
39 (10.2)
|
|
Previous TB-related surgery (n = 445)
|
50 (11.2)
|
|
Baseline XDR-TB
|
22 (4.9)
|
|
Initial treatment outcome
|
|
Successful
|
299 (66.9)
|
|
Cure
|
280 (62.6)
|
|
Treatment Completion
|
19 (4.3)
|
|
Unsuccessful
|
148 (33.1)
|
|
Death
|
30 (6.7)
|
|
Treatment Failure
|
39 (8.7)
|
|
Default
|
78 (17.4)
|
|
Transfer Out
|
1 (0.2)
|
