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Table 2 Software for designing, simulating, and conducting dose-finding trials using rule-based designs and the CRM

From: How to design a dose-finding study using the continual reassessment method

Name Host/Institution Software/Stand-alone Free/Commercial Rule-based/Model-based Description
bcrm [88] CRAN R Free Both Design, run, and simulate trials using the CRM and 3 + 3 design
dfcrm [18] CRAN R Free Model-based Design, run, and simulate trials using the CRM and Time-to-event CRM
crmPack [89] CRAN R Free Both Design, run, and simulate trials using the CRM (includes other model-based designs, joint toxicity-efficacy modelling)
crm [90] IDEAS (RePEc) Stata Free Model-based Run a single trial using the CRM
MoDEsT [91] Lancaster University Stand-alone (online) Free Model-based Design, run, and simulate trials using the CRM
Bayesian CRM for phase I trials [92] University of Virginia Stand-alone (online) Free Model-based Design, run, and simulate trials using the CRM
AplusB [93] MRC Biostatistics Unit, University of Cambridge Stand-alone (online) Free Rule-based Compute exact operating characteristics for 3 + 3 and other rule-based designs
Center for Quantitative Sciences Calculator [94] Vanderbilt University Stand-alone (online) Free Both Simulate trials using the CRM (uses bcrm [88] and dfcrm [18]) and other designs (rule-based/model-based)
CRMSimulator [95] MD Anderson Cancer Center, University of Texas Stand-alone Free Model-based Simulate trials using the CRM
FACTS [96] Berry Consultants Stand-alone Commercial Both Design program for phase I trials using the CRM, plus fixed and adaptive designs for phase II trials
ADDPLAN [97] ICON PLC Stand-alone Commercial Both Design, simulate, and analyse trials using the CRM (includes methods for dose-response modelling)
  1. Abbreviations: CRAN Comprehensive R Archive Network, CRM Continual Reassessment Method, FACTS Fixed and Adaptive Clinical Trial Simulator, MoDEsT Model-based Dose-Escalation Trials, RePEc Research Papers in Economics