Table 2 Software for designing, simulating, and conducting dose-finding trials using rule-based designs and the CRM
From: How to design a dose-finding study using the continual reassessment method
Name | Host/Institution | Software/Stand-alone | Free/Commercial | Rule-based/Model-based | Description |
|---|---|---|---|---|---|
bcrm [88] | CRAN | R | Free | Both | Design, run, and simulate trials using the CRM and 3 + 3 design |
dfcrm [18] | CRAN | R | Free | Model-based | Design, run, and simulate trials using the CRM and Time-to-event CRM |
crmPack [89] | CRAN | R | Free | Both | Design, run, and simulate trials using the CRM (includes other model-based designs, joint toxicity-efficacy modelling) |
crm [90] | IDEAS (RePEc) | Stata | Free | Model-based | Run a single trial using the CRM |
MoDEsT [91] | Lancaster University | Stand-alone (online) | Free | Model-based | Design, run, and simulate trials using the CRM |
Bayesian CRM for phase I trials [92] | University of Virginia | Stand-alone (online) | Free | Model-based | Design, run, and simulate trials using the CRM |
AplusB [93] | MRC Biostatistics Unit, University of Cambridge | Stand-alone (online) | Free | Rule-based | Compute exact operating characteristics for 3 + 3 and other rule-based designs |
Center for Quantitative Sciences Calculator [94] | Vanderbilt University | Stand-alone (online) | Free | Both | Simulate trials using the CRM (uses bcrm [88] and dfcrm [18]) and other designs (rule-based/model-based) |
CRMSimulator [95] | MD Anderson Cancer Center, University of Texas | Stand-alone | Free | Model-based | Simulate trials using the CRM |
FACTS [96] | Berry Consultants | Stand-alone | Commercial | Both | Design program for phase I trials using the CRM, plus fixed and adaptive designs for phase II trials |
ADDPLAN [97] | ICON PLC | Stand-alone | Commercial | Both | Design, simulate, and analyse trials using the CRM (includes methods for dose-response modelling) |