TY - JOUR AU - Iddrisu, Abdul-Karim AU - Gumedze, Freedom PY - 2019 DA - 2019/01/09 TI - An application of a pattern-mixture model with multiple imputation for the analysis of longitudinal trials with protocol deviations JO - BMC Medical Research Methodology SP - 10 VL - 19 IS - 1 AB - The benefit of a given treatment can be evaluated via a randomized clinical trial design. However, protocol deviations may severely compromise treatment effect since such deviations often lead to missing values. The assumption that methods of analysis can account for the missing data cannot be justified and hence methods of analysis based on plausible assumptions should be used. An alternative analysis to the simple imputation methods requires unverifiable assumptions about the missing data. Therefore sensitivity analysis should be performed to investigate the robustness of statistical inferences to alternative assumptions about the missing data. SN - 1471-2288 UR - https://doi.org/10.1186/s12874-018-0639-y DO - 10.1186/s12874-018-0639-y ID - Iddrisu2019 ER -