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Table 1 Non-monotone data: mean \(\sqrt {\text {CD4}}\) count at each visit by treatment arm

From: An application of a pattern-mixture model with multiple imputation for the analysis of longitudinal trials with protocol deviations

  Visit (month)  
Missingness pattern [a] 0 0.5 1 3 6 N (%)
Placebo arm
1 13.14 13.47 13.62 16.24 17.09 44 (15)
2 12.58 13.70 14.76 17.01 - 9 (3)
3 16.90 17.68 20.27 - - 4 (1.4)
4 16.00 12.44 - - - 7 (2.4)
5 11.85 13.06 13.95 - 14.12 7 (2.4)
6 12.19 - - - 14.87 13 (4.4)
7 12.60 13.49 - 16.92 20.60 6 (2)
8 10.65 - - 13.09 14.90 15 (5)
9 - - - 15.59 17.33 4 (1.4)
10 13.17 - 14.29 16.92 17.19 90 (31)
11 - - 16.64 16.92 17.62 16 (5.4)
12 - 13.78 13.77 15.77 16.17 12 (4.1)
13 11.15 - 12.96 - 15.85 9 (3.1)
14 10.77 10.17 - 10.67 - 3 (1)
15 12.89 - 13.20 15.65 - 18 (6)
16 10.64 - - 13.44 - 5 (1.7)
17 13.61 - 12.46 - - 10 (3.4)
18 - 11.33 13.65 17.70 - 4 (1.4)
19 - 13.36 - 14.98 16.76 8 (2.7)
20 - - - - - 0 (0)
21 - - - - - 0 (0)
22 - - 13.00 16.31 - 6 (2)
23 - - 14.64 - 15.62 3 (1)
24 - 18.19 - 14.04 - 1 (0.3)
25 - 18.03 19.52 - 15.36 1 (0.3)
All patients mean (std) 12.86 (0.361) 13.45 (0.533) 14.18 (0.368) 16.17 (0.349) 16.77 (0.334) 294 (100)
Prednisolone arm
1 13.18 15.52 14.70 16.76 16.822 46 (16)
2 19.89 19.27 19.51 21.17 - 5 (2)
3 9.04 12.26 12.49 - - 12 (4.1)
4 11.64 11.43 - - - 10 (3.4)
5 2.83 3.61 3.32 - 4.47 1 (0.3)
6 9.62 - - - 14.15 11 (4)
7 13.84 16.89 - 18.47 18.12 4 (1.4)
8 11.06 - - 14.57 14.29 28 (10)
9 - - - 19.10 19.57 5 (2)
10 12.42 - 13.03 15.83 16.09 76 (26)
11 - - 11.85 16.16 15.82755 13 (4.4)
12 - 12.27 13.99 15.88 15.66 14 (5)
13 9.07 - 9.26 - 15.92 12 (4.1)
14 - - - - - 0 (0)
15 12.52 - 13.21 15.54 - 14 (5)
16 14.12 - - 15.73 - 9 (3.1)
17 8.12 - 10.74 - - 13 (4.4)
18 - 14.35 14.73 16.00 - 2 (0.7)
19 - 17.10 - 20.95 21.59 4 (1.4)
20 - 15.07 13.10 - - 3 (1)
21 - 10.21 - - 10.80 2 (0.7)
22 - - 15.07 16.78 - 3 (1)
23 - - 13.09 - 9.32 3 (1)
24 - 18.19 - 14.04 - 1 (0.3)
25 - 8.35 8.20 - 13.36 2 (0.7)
All patients mean (std) 11.89 (0.333) 106, 14.27 (0.575) 219, 13.12 (0.397) 224, 16.20 (0.344) 221, 15.86 (0.348) 293 (100)
  1. aMissingness patterns: 1 = CD4 count data at all visits, 2 = CD4 count data at all visits except 6, 3 = CD4 count data at all visits except 6 and 3, 4 = CD4 count data at all visits except 6, 3, and 1, 5 = CD4 count data at all visits except visit 3, 6 = CD4 count data at baseline and visit 6 etc