Table 1 Non-monotone data: mean \(\sqrt {\text {CD4}}\) count at each visit by treatment arm

Placebo arm

1

13.14

13.47

13.62

16.24

17.09

44 (15)

2

12.58

13.70

14.76

17.01

-

9 (3)

3

16.90

17.68

20.27

-

-

4 (1.4)

4

16.00

12.44

-

-

-

7 (2.4)

5

11.85

13.06

13.95

-

14.12

7 (2.4)

6

12.19

-

-

-

14.87

13 (4.4)

7

12.60

13.49

-

16.92

20.60

6 (2)

8

10.65

-

-

13.09

14.90

15 (5)

9

-

-

-

15.59

17.33

4 (1.4)

10

13.17

-

14.29

16.92

17.19

90 (31)

11

-

-

16.64

16.92

17.62

16 (5.4)

12

-

13.78

13.77

15.77

16.17

12 (4.1)

13

11.15

-

12.96

-

15.85

9 (3.1)

14

10.77

10.17

-

10.67

-

3 (1)

15

12.89

-

13.20

15.65

-

18 (6)

16

10.64

-

-

13.44

-

5 (1.7)

17

13.61

-

12.46

-

-

10 (3.4)

18

-

11.33

13.65

17.70

-

4 (1.4)

19

-

13.36

-

14.98

16.76

8 (2.7)

20

-

-

-

-

-

0 (0)

21

-

-

-

-

-

0 (0)

22

-

-

13.00

16.31

-

6 (2)

23

-

-

14.64

-

15.62

3 (1)

24

-

18.19

-

14.04

-

1 (0.3)

25

-

18.03

19.52

-

15.36

1 (0.3)

All patients mean (std)

12.86 (0.361)

13.45 (0.533)

14.18 (0.368)

16.17 (0.349)

16.77 (0.334)

294 (100)

Prednisolone arm

1

13.18

15.52

14.70

16.76

16.822

46 (16)

2

19.89

19.27

19.51

21.17

-

5 (2)

3

9.04

12.26

12.49

-

-

12 (4.1)

4

11.64

11.43

-

-

-

10 (3.4)

5

2.83

3.61

3.32

-

4.47

1 (0.3)

6

9.62

-

-

-

14.15

11 (4)

7

13.84

16.89

-

18.47

18.12

4 (1.4)

8

11.06

-

-

14.57

14.29

28 (10)

9

-

-

-

19.10

19.57

5 (2)

10

12.42

-

13.03

15.83

16.09

76 (26)

11

-

-

11.85

16.16

15.82755

13 (4.4)

12

-

12.27

13.99

15.88

15.66

14 (5)

13

9.07

-

9.26

-

15.92

12 (4.1)

14

-

-

-

-

-

0 (0)

15

12.52

-

13.21

15.54

-

14 (5)

16

14.12

-

-

15.73

-

9 (3.1)

17

8.12

-

10.74

-

-

13 (4.4)

18

-

14.35

14.73

16.00

-

2 (0.7)

19

-

17.10

-

20.95

21.59

4 (1.4)

20

-

15.07

13.10

-

-

3 (1)

21

-

10.21

-

-

10.80

2 (0.7)

22

-

-

15.07

16.78

-

3 (1)

23

-

-

13.09

-

9.32

3 (1)

24

-

18.19

-

14.04

-

1 (0.3)

25

-

8.35

8.20

-

13.36

2 (0.7)

All patients mean (std)

11.89 (0.333)

106, 14.27 (0.575)

219, 13.12 (0.397)

224, 16.20 (0.344)

221, 15.86 (0.348)

293 (100)