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Table 3 Monotone data: mean \(\sqrt {\text {CD4}}\) count at each visit by dropout pattern and treatment arm

From: An application of a pattern-mixture model with multiple imputation for the analysis of longitudinal trials with protocol deviations

 

Dropout time (months)

 

Dropout pattern [a]

0

0.5

1

3

6

N (%)

Placebo arm

4

13.14

13.47

13.62

16.24

17.09

44 (69)

3

12.58

13.702

14.76

17.01

-

9 (14)

2

16.90

17.68

20.27

-

-

4 (6)

1

15.98

12.44

-

-

-

7 (11)

All patients mean (std)

13.61 (5.84)

13.65 (4.97)

14.26 (5.32)

16.37 (4.85)

17.09 (5.14)

64 (100)

Prednisolone arm

4

13.18

15.52

14.70

16.76

16.82

46 (63)

3

19.89

19.27

19.51

21.17

-

5 (7)

2

9.04

12.26

12.49

-

-

12 (16)

1

11.64

11.43

-

-

-

10 (14)

All patients mean (std)

12.75 (5.10)

14.68 (5.71)

14.66 (5.84)

17.19 (4.80)

16.82 (4.72)

73 (100)

  1. aDropout patterns: 4 = subjects who had all measurements up to 6 months (completers), 3 = subjects who had measurements up to 3 months, 2 = subjects who had measurements up to 1 month, and 1 = subjects who had measurements up to 2 weeks