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Table 3 Monotone data: mean \(\sqrt {\text {CD4}}\) count at each visit by dropout pattern and treatment arm

From: An application of a pattern-mixture model with multiple imputation for the analysis of longitudinal trials with protocol deviations

  Dropout time (months)  
Dropout pattern [a] 0 0.5 1 3 6 N (%)
Placebo arm
4 13.14 13.47 13.62 16.24 17.09 44 (69)
3 12.58 13.702 14.76 17.01 - 9 (14)
2 16.90 17.68 20.27 - - 4 (6)
1 15.98 12.44 - - - 7 (11)
All patients mean (std) 13.61 (5.84) 13.65 (4.97) 14.26 (5.32) 16.37 (4.85) 17.09 (5.14) 64 (100)
Prednisolone arm
4 13.18 15.52 14.70 16.76 16.82 46 (63)
3 19.89 19.27 19.51 21.17 - 5 (7)
2 9.04 12.26 12.49 - - 12 (16)
1 11.64 11.43 - - - 10 (14)
All patients mean (std) 12.75 (5.10) 14.68 (5.71) 14.66 (5.84) 17.19 (4.80) 16.82 (4.72) 73 (100)
  1. aDropout patterns: 4 = subjects who had all measurements up to 6 months (completers), 3 = subjects who had measurements up to 3 months, 2 = subjects who had measurements up to 1 month, and 1 = subjects who had measurements up to 2 weeks