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Table 4 Monotone data: Parameter estimates from de jure and de facto analyses

From: An application of a pattern-mixture model with multiple imputation for the analysis of longitudinal trials with protocol deviations

  Prednisolone    Time    Prednisolone x Time    ART    Prednisolone x ART    Age   
Analysis Est s.e. p-value Est s.e. p-value Est. s.e. p-value Est. s.e. p-value Est. s.e. p-value Est. s.e. p-value
MI 0.56 0.791 0.481 0.39 0.140 0.005 0.13 0.195 0.494 2.76 0.689 <0.0001 -1.12 0.966 0.245 -3.12 1.372 0.023
LMCF 0.46 0.870 0.597 0.34 0.092 <0.0001 -0.05 0.146 0.751 2.81 0.548 <0.0001 -0.75 0.875 0.400 -3.06 1.529 0.046
J2R (P-) 0.42 0.845 0.619 0.53 0.094 <0.0001 0.04 0.161 0.825 2.33 0.556 <0.0001 -0.96 0.842 0.260 -3.00 1.509 0.047
J2R (P+) 0.42 0.849 0.623 0.42 0.103 <0.0001 0.02 0.130 0.879 2.57 0.544 <0.0001 -0.96 0.786 0.275 -3.00 1.518 0.048
CDR (P-) 0.46 0.851 0.586 0.52 0.094 <0.0001 0.05 0.148 0.729 2.33 0.56 <0.0001 -0.96 0.844 0.259 -2.97 1.507 0.049
CDR (P+) 0.46 0.863 0.593 0.41 0.113 0.001 0.027 0.147 0.852 2.59 0.589 <0.0001 -0.88 0.882 0.3230 -2.98 1.52 0.050
CR (P-) 0.43 0.852 0.613 0.53 0.093 <0.0001 0.002 0.144 0.990 2.34 0.554 <0.0001 -0.87 0.815 0.288 -3.00 1.509 0.047
CR (P+) 0.44 0.858 0.608 0.43 0.114 <0.0001 0.006 0.137 0.966 2.55 0.579 <0.0001 -0.839 0.848 0.328 -3.00 1.521 0.049