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Table 5 Combined non-monotone and monotone data: Parameter estimates from de jure and de facto analyses

From: An application of a pattern-mixture model with multiple imputation for the analysis of longitudinal trials with protocol deviations

  Prednisolone Time Prednisolone x Time ART Prednisolone x ART Age
Analysis Est s.e. p-value Est s.e. p-value Est. s.e. p-value Est. s.e. p-value Est. s.e. p-value Est. s.e. p-value
MI -0.61 0.42 0.150 0.51 0.079 <0.0001 -0.004 0.115 0.974 1.50 0.394 <0.0001 0.21 0.581 0.718 -2.51 0.667 <0.0001
LMCF -0.76 0.446 0.088 0.39 0.045 <0.0001 0.03 0.081 0.707 2.21 0.263 <0.0001 -0.04 0.406 0.924 -2.29 0.799 0.004
J2R (P-) -0.36 0.486 0.455 0.47 0.047 <0.0001 0.04 0.076 0.561 2.03 0.258 <0.0001 -0.30 0.404 0.457 -2.25 0.779 0.004
J2R (P+) -0.36 0.512 0.489 .45 0.052 <0.0001 0.03 0.080 0.737 2.06 0.321 <0.0001 -0.16 0.438 0.712 -2.25 0.795 0.001
CDR (P-) -0.61 0.444 0.168 0.47 0.047 <0.0001 .05 0.083 0.577 2.04 0.259 <0.0001 -0.21 0.379 0.582 -2.27 0.783 0.0004
CDR (P+) -0.59 0.471 0.216 0.46 0.051 <0.0001 0.02 0.083 0.849 1.93 0.288 <0.0001 -0.03 0.397 0.939 -2.24 0.790 0.005
CR (P-) -0.64 0.438 0.143 0.47 0.047 <0.0001 0.04 0.075 0.644 2.04 0.258 <0.0001 -0.15 0.376 0.688 -2.29 0.782 0.003
CR (P+) -0.66 0.451 0.142 0.46 0.050 <0.0001 0.02 0.079 0.792 1.91 0.288 <0.0001 -0.01 0.405 0.979 -2.22 0.792 0.001