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Table 6 MCAR mechanism by missingness rate

From: An application of a pattern-mixture model with multiple imputation for the analysis of longitudinal trials with protocol deviations

Missingness rates

 

Treatment

Time

Treatment x Time

Coverage probability

5%

Analysis

Bias

RMSE

Bias

RMSE

Bias

RMSE

Treatment

Time

Treatment x Time

 

ML

-0.063

0.127

-0.005

0.015

0.028

0.033

94.10%

96.40%

93.50%

 

MI

-0.0602

0.127

0.001

0.020

0.021

0.031

95.50%

94.10%

95.80%

 

LMCF

-0.079

0.137

-0.049

0.051

0.032

0.039

93.50%

95.00%

95.60%

 

J2R (P-)

-0.100

0.149

-0.006

0.016

0.050

0.054

92.70%

95.40%

94.30%

 

CDR (P-)

-0.090

0.141

-0.006

0.016

0.040

0.046

93.10%

95.30%

94.20%

 

CR (P-)

-0.095

0.146

-0.006

0.016

0.045

0.050

92.20%

95.30%

94.80%

10%

          
 

ML

0.112

0.157

-0.017

0,022

0.028

0.035

89.50%

94.50%

95.00%

 

MI

0.112

0.158

-0.018

0.024

0.030

0.040

90.50%

95.50%

95.00%

 

LMCF

0.095

0.150

-0.103

0.104

0.040

0.046

92.50%

87.50%

95.50%

 

J2R (P-)

0.072

0.133

-0.015

0.020

0.054

0.058

94.5%

87.50%

94.50%

 

CDR (P-)

0.088

0.143

-0.015

0.020

0.046

0.051

92.50%

86.50%

96.00%

 

CR (P-)

0.078

0.136

-0.015

0.020

0.052

0.057

93.50%

88.50%

95.50%

20%

          
 

ML

-0.032

0.12

-0.0024

0.017

0.024

0.034

95.00%

94.50%

95.00%

 

MI

-0.042

0.124

-0.005

0.022

0.033

0.045

94.50%

95.50%

95.00%

 

LMCF

-0.099

0.154

-0.183

0.183

0.078

0.083

93.50%

90.50% %

94.50%

 

J2R (P-)

-0.122

0.164

0.0002

0.016

0.092

0.100

89.50%

95.00%

94.50%

 

CDR (P-)

-0.074

0.134

0.0002

0.016

0.057

0.063

95.50%

95.00%

93.50%

 

CR (P-)

-0.099

0.149

0.0002

0.016

0.073

0.075

94.50%

95.00%

94.50%

30%

          
 

ML

-0.092

0.149

-0.052

0.055

0.043

0.051

94.30%

94.50%

95.10%

 

MI

-0.050

136

-0.030

0.039

0.005

0.037

94.40%

95.20%

95.80%

 

LMCF

-0.136

0.184

-0.279

0.280

0.081

0.086

89.10%

85.70%

90.20%

 

J2R (P-)

-0.220

0.252

-0.059

0.062

0.138

0.141

85.20%

94.50%

87.40%

 

CDR (P-)

-0.160

0.200

-0.059

0.062

0.094

0.098

90.50%

94.10%

95.30%

 

CR (P-)

-0.197

0.216

-0.059

0.062

0.109

0.112

90.90%

93.20%

92.70%

50%

          
 

ML

0.036

0.123

0.0004

0.022

0.009

0.033

96.60%

95.30%

95.40%

 

MI

0.039

0.136

-0.006

0.031

0.026

0.051

95.30%

95.10%

94.60%

 

LMCF

-0.045

0.129

-0.360

0.360

0.084

0.088

94.30%

89.10%

95.40%

 

J2R (P-)

-0.112

0.159

0.0004

0.023

0.127

0.130

89.50%

95.10%

90.60%

 

CDR (P-)

-0.045

0.121

0.0004

0.023

0.088

0.089

94.70%

95.20%

93.40%

 

CR (P-)

-0.087

0.142

0.0004

0.023

0.112

0. 115

91.20%

95.20%

89.50%