An application of a pattern-mixture model with multiple imputation for the analysis of longitudinal trials with protocol deviations

Iddrisu, Abdul-Karim; Gumedze, Freedom

doi:10.1186/s12874-018-0639-y

Table 7 MAR mechanism by missing rate

From: An application of a pattern-mixture model with multiple imputation for the analysis of longitudinal trials with protocol deviations

Missingness rates		Treatment		Time		Treatment x Time		Coverage probability
5%	Analysis	Bias	RMSE	Bias	RMSE	Bias	RMSE	Treatment	Time	Treatment x Time
	ML	-0.153	0.189	-0.0112	0.018	0.009	0.022	87.50%	95.30%	95.10%
	MI	-0.155	0.191	-0.008	0.017	0.004	0.022	86.90%	95.50%	94.50%
	LMCF	-0.155	0.190	-0.033	0.036	0.011	0.023	85.90%	95.10%	95.30%
	J2R (P-)	-0.172	0.205	-0.012	0.019	0.023	0.031	82.50%	94.90%	95.20%
	CDR (P-)	-0.160	0.195	-0.012	0.019	0.015	0.025	87.30%	95.10%	94.50%
	CR (P-)	-0.165	0.199	-0.012	0.018	0.019	0. 027	83.70%	94.30%	95.50%
10%
	ML	0.062	0.125	0.003	0.015	0.011	0.024	94.50%	95.10%	94.20%
	MI	0.059	0.125	-0.007	0.017	0.016	0.030	94.20%	95.10%	94.30%
	LMCF	0.031	0.11	-0.087	0.088	0.034	0.040	95.10%	93.30%	95.20%
	J2R (P-)	0.013	0.110	-0.004	0.016	0.044	0.050	94.50%	95.20%	96.60%
	CDR (P-)	0.036	0.115	-0.004	0.016	0.032	0.040	95.69%	95.90%	95.20%
	CR (P-)	0.022	0.111	-0.004	0.016	0.040	0. 045	95.30%	95.10%	95.60%
20%
ML	-0.043	0.012	-0.0061	0.018	0.009	0.025	94.10%	94.50%	95.30%
	MI	-0.036	0.125	-0.013	0.026	0.013	0.033	95.00%	94.50%	95.30%
	LMCF	-0.127	0.175	-0.180	0.180	0.066	0.070	87.90%	84.40%	94.50%
	J2R (P-)	-0.131	0.177	-0.002	0.017	0.078	0.083	86.80%	95.30%	95.10%
	CDR (P-)	-0.102	0.155	-0.002	0.017	0.054	0.059	85.30%	96.10%	95.50%
	CR (P-)	-0.115	0.163	-0.002	0.017	0.063	0. 067	89.60%	95.10%	95.40%
30%
	ML	0.062	0.125	0.003	0.015	0.011	0.024	94.50%	95.40%	96.30%
	MI	0.059	0.125	-0.007	0.017	0.016	0.030	95.10%	94.50%	96.20%
	LMCF	0.031	0.11	-0.087	0.088	0.034	0.040	94.30%	95.50%	94.70%
	J2R (P-)	0.013	0.110	-0.004	0.016	0.044	0.050	94.50%	96.10%	95.90%
	CDR (P-)	0.036	0.115	-0.004	0.016	0.032	0.040	95.10%	94.30%	95.50%
	CR (P-)	0.022	0.111	-0.004	0.016	0.040	0.045	94.50%	95.60%	96.20%
50%
	ML	0.153	0.193	0.055	0.059	-0.071	0.077	87.80%	94.50%	96.10%
	MI	0.144	0.195	0.050	0.059	-0.063	0.077	86.30%	95.40%	96.10%
	LMCF	0.066	0.143	0.374	0.374	0.090	0.094	93.10%	67.80%	92.50%
	J2R (P-)	0.142	0.185	0.054	0.060	0.122	0.125	87.70%	96.10%	89.50%
	CDR (P-)	-0.039	0.124	0.054	0.060	0.056	0.061	95.50%	94.80%	96.40%
	CR (P-)	-0.102	0.156	0.54	0.060	0.095	0.098	93.10%	92.70%	95.40%

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