Fig. 4
From: Evidence-based sizing of non-inferiority trials using decision models
Impact of sensitivity and disutility of colonoscopy on appropriate non-inferiority margin for 10-yearly vs. 5-yearly surveillance. Line of QALY equipoise gives for each level of disutility the level of CRC risk in 10-yearly surveillance arm for which QALYs with 10-yearly surveillance are equal to QALYs with 5-yearly surveillance. Values given with this line are associated sample sizes to demonstrate non-inferiority with 90% power