TY - JOUR AU - Perperoglou, Aris AU - Sauerbrei, Willi AU - Abrahamowicz, Michal AU - Schmid, Matthias PY - 2019 DA - 2019/03/06 TI - A review of spline function procedures in R JO - BMC Medical Research Methodology SP - 46 VL - 19 IS - 1 AB - With progress on both the theoretical and the computational fronts the use of spline modelling has become an established tool in statistical regression analysis. An important issue in spline modelling is the availability of user friendly, well documented software packages. Following the idea of the STRengthening Analytical Thinking for Observational Studies initiative to provide users with guidance documents on the application of statistical methods in observational research, the aim of this article is to provide an overview of the most widely used spline-based techniques and their implementation in R. SN - 1471-2288 UR - https://doi.org/10.1186/s12874-019-0666-3 DO - 10.1186/s12874-019-0666-3 ID - Perperoglou2019 ER -