BMC Medical Research Methodology

Table 3 Results for the simulation 2(b): outcome variables were measured on two time-points for 40% trials and on three time-points for 60% trials

From: Efficient two-step multivariate random effects meta-analysis of individual participant data for longitudinal clinical trials using mixed effects models

	N = 5		N = 10		N = 15
	τ² = 0.10	τ² = 0.20	τ² = 0.10	τ² = 0.20	τ² = 0.10	τ² = 0.20
μ₂ = 0.14
Mean	0.140	0.142	0.144	0.136	0.136	0.139
SE	1.026	1.026	0.693	0.702	0.483	0.559
\( \widehat{\mathrm{SE}} \)	0.989	1.004	0.681	0.690	0.475	0.561
Coverage Rate	0.947	0.950	0.948	0.946	0.948	0.953
Power	0.057	0.052	0.058	0.058	0.061	0.053
μ₄ = 0.83
Mean	0.825	0.822	0.823	0.828	0.873	0.836
SE	0.546	0.584	0.377	0.404	0.283	0.329
\( \widehat{\mathrm{SE}} \)	0.537	0.574	0.376	0.402	0.257	0.328
Coverage Rate	0.948	0.950	0.950	0.947	0.907	0.947
Power	0.347	0.316	0.591	0.548	0.892	0.717
μ₅ = −0.46
Mean	−0.459	−0.459	−0.460	−0.459	−0.460	−0.461
SE	0.147	0.204	0.103	0.143	0.073	0.118
\( \widehat{\mathrm{SE}} \)	0.143	0.200	0.102	0.143	0.073	0.117
Coverage Rate	0.931	0.932	0.944	0.944	0.944	0.945
Power	0.874	0.625	0.994	0.890	1.000	0.974
μ₇ = 0.14
Mean	0.145	0.145	0.136	0.135	0.138	0.141
SE	0.295	0.359	0.207	0.245	0.147	0.202
\( \widehat{\mathrm{SE}} \)	0.291	0.346	0.206	0.245	0.145	0.201
Coverage Rate	0.943	0.936	0.947	0.950	0.946	0.949
Power	0.088	0.083	0.105	0.082	0.167	0.110
μ₉ = 0.05
Mean	0.051	0.052	0.051	0.055	0.049	0.050
SE	0.185	0.263	0.133	0.184	0.093	0.151
\( \widehat{\mathrm{SE}} \)	0.178	0.252	0.128	0.181	0.091	0.149
Coverage Rate	0.925	0.927	0.935	0.940	0.941	0.943
Power	0.086	0.080	0.084	0.070	0.089	0.070
μ₁₀ = −0.06
Mean	−0.062	− 0.063	− 0.060	− 0.060	− 0.060	− 0.059
SE	0.150	0.205	0.106	0.146	0.075	0.118
\( \widehat{\mathrm{SE}} \)	0.147	0.203	0.105	0.145	0.074	0.118
Coverage Rate	0.934	0.937	0.942	0.943	0.947	0.948
Power	0.084	0.074	0.096	0.079	0.130	0.083

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ISSN: 1471-2288

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