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Table 4 Results of the IPD meta-analysis of 4 clinical trials for new generation antidepressants

From: Efficient two-step multivariate random effects meta-analysis of individual participant data for longitudinal clinical trials using mixed effects models

  One-step method (Fixed effects model) Two-step method (Fixed effects model) Two-step method (Random effects model)
Estimate 95%CI P-value Estimate 95%CI P-value Estimate 95%CI P-value
μ 1 2.100 −0.407 4.606 0.101 1.353 −0.884 3.590 0.236 −0.040 −2.313 2.234 0.973
μ 2 −0.029 −2.813 2.755 0.984 0.284 −2.183 2.750 0.822 0.193 −2.311 2.697 0.880
μ 3 2.829 1.574 4.084 <  0.001 2.790 1.537 4.043 <  0.001 2.933 1.660 4.207 <  0.001
μ 4 1.865 0.604 3.125 0.004 1.812 0.553 3.072 0.005 1.576 0.297 2.856 0.016
μ 5 0.979 −0.289 2.247 0.130 0.985 −0.282 2.252 0.128 0.846 −0.442 2.134 0.198
μ 6 −0.547 −0.663 −0.430 <  0.001 −0.511 −0.615 −0.407 <  0.001 −0.456 −0.571 −0.341 <  0.001
μ 7 1.022 0.487 1.558 <  0.001 1.019 0.486 1.551 <  0.001 1.081 0.544 1.618 <  0.001
μ 8 0.551 0.014 1.088 0.044 0.536 0.002 1.071 0.049 0.577 0.038 1.115 0.036
μ 9 0.110 −0.431 0.651 0.689 0.104 − 0.435 0.642 0.705 0.141 −0.402 0.684 0.610
μ 10 0.193 0.137 0.249 <  0.001 0.196 0.140 0.251 <  0.001 0.189 0.116 0.261 <  0.001
μ 11 0.138 0.082 0.194 <  0.001 0.141 0.085 0.197 <  0.001 0.150 0.077 0.222 <  0.001
μ 12 0.045 −0.011 0.102 0.117 0.045 −0.011 0.102 0.115 0.049 −0.024 0.123 0.185
μ 13 −0.046 −0.175 0.082 0.479 −0.063 −0.177 0.051 0.278 −0.066 −0.190 0.058 0.294