Efficient two-step multivariate random effects meta-analysis of individual participant data for longitudinal clinical trials using mixed effects models

Table 4 Results of the IPD meta-analysis of 4 clinical trials for new generation antidepressants

	One-step method (Fixed effects model)				Two-step method (Fixed effects model)				Two-step method (Random effects model)
	Estimate	95%CI		P-value	Estimate	95%CI		P-value	Estimate	95%CI		P-value
μ ₁	2.100	−0.407	4.606	0.101	1.353	−0.884	3.590	0.236	−0.040	−2.313	2.234	0.973
μ ₂	−0.029	−2.813	2.755	0.984	0.284	−2.183	2.750	0.822	0.193	−2.311	2.697	0.880
μ ₃	2.829	1.574	4.084	< 0.001	2.790	1.537	4.043	< 0.001	2.933	1.660	4.207	< 0.001
μ ₄	1.865	0.604	3.125	0.004	1.812	0.553	3.072	0.005	1.576	0.297	2.856	0.016
μ ₅	0.979	−0.289	2.247	0.130	0.985	−0.282	2.252	0.128	0.846	−0.442	2.134	0.198
μ ₆	−0.547	−0.663	−0.430	< 0.001	−0.511	−0.615	−0.407	< 0.001	−0.456	−0.571	−0.341	< 0.001
μ ₇	1.022	0.487	1.558	< 0.001	1.019	0.486	1.551	< 0.001	1.081	0.544	1.618	< 0.001
μ ₈	0.551	0.014	1.088	0.044	0.536	0.002	1.071	0.049	0.577	0.038	1.115	0.036
μ ₉	0.110	−0.431	0.651	0.689	0.104	− 0.435	0.642	0.705	0.141	−0.402	0.684	0.610
μ ₁₀	0.193	0.137	0.249	< 0.001	0.196	0.140	0.251	< 0.001	0.189	0.116	0.261	< 0.001
μ ₁₁	0.138	0.082	0.194	< 0.001	0.141	0.085	0.197	< 0.001	0.150	0.077	0.222	< 0.001
μ ₁₂	0.045	−0.011	0.102	0.117	0.045	−0.011	0.102	0.115	0.049	−0.024	0.123	0.185
μ ₁₃	−0.046	−0.175	0.082	0.479	−0.063	−0.177	0.051	0.278	−0.066	−0.190	0.058	0.294

ISSN: 1471-2288