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Table 2 Alonso et al. [21] dataset with dicothomized outcome. Results of logistic, Firth and WIP model by number of events in Control nC and number of events in Vaccinated group (nV)

From: Assessing correlates of protection in vaccine trials: statistical solutions in the context of high vaccine efficacy

n C

n V

Logistic

Firth

WIP

  

\(\hat \beta \)

\(\hat Var(\hat \beta)\)

\(\hat \beta \)

\(\hat Var(\hat \beta)\)

\(\hat \beta \)

\(\hat Var(\hat \beta)\)

0

0

0.00

2.33e+09

0.00

1.15

0.00

1.28

1

0

-9.18

7.85e+06

-0.60

0.79

-0.59

0.65

2

0

-9.59

7.85e+06

-0.91

0.72

-0.90

0.58

3

0

-9.36

2.89e+06

-1.14

0.69

-1.15

0.57

4

0

-9.58

2.89e+06

-1.34

0.68

-1.37

0.58

5

0

-9.78

2.89e+06

-1.52

0.68

-1.59

0.61

6

0

-9.99

2.89e+06

-1.71

0.68

-1.80

0.64

7

0

-10.21

2.89e+06

-1.90

0.69

-2.04

0.69

8

0

-10.98

7.85e+06

-2.13

0.72

-2.33

0.77

9

0

-11.38

7.85e+06

-2.45

0.79

-2.73

0.92

10

0

-25.57

2.33e+09

-3.04

1.15

-3.84

1.91

1

1

0.00

5.60e-01

0.00

0.42

0.00

0.35

3

1

-0.67

4.00e-01

-0.54

0.33

-0.49

0.26

9

2

-1.79

4.30e-01

-1.53

0.35

-1.51

0.30

2

3

0.27

2.80e-01

0.23

0.26

0.21

0.21