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Fig. 4 | BMC Medical Research Methodology

Fig. 4

From: Sample size calculation for estimating key epidemiological parameters using serological data and mathematical modelling

Fig. 4

Parvovirus B19 serological data: mean, median, and 95% confidence interval for the overall seroprevalence (left) and overall force of infection (right) over 500 simulations as a function of the total number of sampled individuals (N) for the Maternally-derived immunity-Susceptible-Infectious-Recovered (MSIR) model with piecewise constant force of infection (top), the exponentially damped model (middle), and the MSIR model allowing for age-specific waning of disease-acquired antibodies and boosting of low immunity (MSIRWb-ext AW) model (bottom). “True” overall seroprevalence is the estimated overall seroprevalence using the models on the observed serological data (with integer age values)

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