TY - JOUR AU - Shan, Guogen AU - Zhang, Hua PY - 2019 DA - 2019/04/03 TI - Two-stage optimal designs with survival endpoint when the follow-up time is restricted JO - BMC Medical Research Methodology SP - 74 VL - 19 IS - 1 AB - Survival endpoint is frequently used in early phase clinical trials as the primary endpoint to assess the activity of a new treatment. Existing two-stage optimal designs with survival endpoint either over estimate the sample size or compute power outside the alternative hypothesis space. SN - 1471-2288 UR - https://doi.org/10.1186/s12874-019-0696-x DO - 10.1186/s12874-019-0696-x ID - Shan2019 ER -