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Table 3 Simulated TIE and power of the proposed two-stage minimax and optimal designs in Table 2

From: Two-stage optimal designs with survival endpoint when the follow-up time is restricted

  

Minimax design

Optimal design

Power

θ

TIE

Power

TIE

Power

90%

15

0.040 (0.036,0.044)

0.907 (0.901,0.913)

0.037 (0.033,0.041)

0.903 (0.898,0.909)

95%

15

0.041 (0.037,0.045)

0.957 (0.953,0.961)

0.038 (0.035,0.042)

0.955 (0.951,0.959)

90%

30

0.040 (0.037,0.044)

0.911 (0.905,0.916)

0.039 (0.035,0.043)

0.910 (0.904,0.916)

95%

30

0.042 (0.038,0.046)

0.959 (0.955,0.963)

0.040 (0.036,0.044)

0.958 (0.954,0.962)

90%

50

0.041 (0.037,0.045)

0.911 (0.905,0.916)

0.040 (0.037,0.044)

0.909 (0.903,0.914)

95%

50

0.042 (0.038,0.046)

0.960 (0.956,0.963)

0.041 (0.037,0.045)

0.959 (0.955,0.963)

  1. The 95% confidence intervals for the parameters of interest are computed using 1000 simulations where 10,000 designs are simulated in each simulation