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Fig. 1 | BMC Medical Research Methodology

Fig. 1

From: Prospective multicenter randomized patient recruitment and sample collection to enable future measurements of sputum biomarkers of inflammation in an observational study of cystic fibrosis

Fig. 1

Shipping Effects on HMGB-1 Measurements. Overnight shipping of refrigerated unfractionated sputum samples from seven patients was associated with a statistically significant increase in ELISA measurements of HMGB-1, especially for low values. Although the values were correlated with values from samples that were fractionated and frozen prior to shipping (see text), the large and somewhat unpredictable sizes of differences in values and the compressed range of values overall suggested that on-site processing of samples would reduce measurement errors and better enable analyses involving HMGB-1

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