Table 1 Scenarios 20 and 28 – performance measures for estimation of control arm RMST
Scenario details | Method | Percent bias | Empirical SE of % bias | RMSE of % bias | Coverage (%) | Convergence (%) |
|---|---|---|---|---|---|---|
Scenario number: 20 True RMST: Control: 357 Experimental: 430 Mean switch: 57% True ave. HR: 0.57 True ave. AF: 1.53 Mean censored: 50% | No switching | 0.0 | 3.7 | 3.7 | 94.4 | 100.0 |
ITT | 7.5 | 3.4 | 8.3 | 46.7 | 100.0 | |
TSE | −2.3 | 6.9 | 7.3 | 97.8 | 100.0 | |
TSEnr | 3.5 | 3.9 | 5.3 | 86.1 | 100.0 | |
TSEipcw | −5.1 | 16.3 | 17.1 | 96.0 | 95.8 | |
min/max MC error | 0.1/0.5 | 0.1/0.4 | 0.1/0.5 | 0.5/1.6 | – | |
Scenario number: 28 True RMST: Control: 228 Experimental: 322 Mean switch: 57% True ave. HR: 0.56 True ave. AF: 1.85 Mean censored: 26% | No switching | −0.1 | 5.7 | 5.7 | 94.7 | 100.0 |
ITT | 15.1 | 5.5 | 16.0 | 29.1 | 100.0 | |
TSE | −3.5 | 9.1 | 9.8 | 93.0 | 100.0 | |
TSEnr | 4.0 | 6.5 | 7.6 | 91.6 | 100.0 | |
TSEipcw | 1.1 | 11.3 | 11.3 | 97.1 | 99.9 | |
min/max MC error | 0.2/0.4 | 0.1/0.3 | 0.1/0.8 | 0.5/1.4 | – |