Incorporating individual historical controls and aggregate treatment effect estimates into a Bayesian survival trial: a simulation study

Table 2 Impact of individual historical data in conflict with new data in terms of survival distribution for S27^a

^aResults correspond to scenario S27 defined with Weibull survival distribution for the historical control data and piecewise exponential distribution for the new data with HR = 0.786 and analysed with ω = 0 either with a Weibull model (W/P/W) or with a piecewise exponential model (W/P/P). These results are compared to scenario S3, given as a benchmark and defined by commensurate historical and new control data which follow a Weibull distribution, and are analysed with a Weibull model (W/W/W)

ISSN: 1471-2288