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Fig. 6 | BMC Medical Research Methodology

Fig. 6

From: Development of an algorithm for evaluating the impact of measurement variability on response categorization in oncology trials

Fig. 6

95% confidence intervals and 95% central ranges depending on the different observed results and the characteristics of the trial data. a When the baseline lesion size is 30 mm and the distribution of percent change is −30 ± N(0, 52) (b) When the baseline lesion size is 100 mm and the distribution of percent change is −30±N (0, 52) (c) When the baseline lesion size is 30 mm and the distribution of percent change is −30 ± N(20, 52) (d) When the baseline lesion size is 100 mm and the distribution of percent change is −30 ± N(20, 52). Gray lines: the observed objective response rate (ORR) and 95% confidence interval; Black lines: median and 95% central range from the tool

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