Table 4 Excess hazard ratios with Cox and RBS model. Results of the application on prostate cancer data
From: Correcting for misclassification and selection effects in estimating net survival in clinical trials
Variable & modalities | Cox model | RBS model |
|---|---|---|
EHR [95% CI] | EHR [95% CI] | |
Treatment | ||
High-dose DES | 0.43 [0.30; 0.64] | 0.62 [0.40; 0.96] |
Low-dose DES | ||
Age (centered) | 0.97 [0.95; 1.00] | 0.98 [0.95; 1.01] |
Weight index a | ||
< 80 | 1.45 [0.75; 2.81] | 2.05 [1.04; 4.05] |
80–99 | 1.29 [0.87; 1.92] | 1.73 [1.13; 2.66] |
≥100 | ||
Performance rating | ||
Limited activity | 1.49 [0.87; 2.52] | 1.62 [0.98; 2.66] |
Normal activity | ||
History of cardiovascular disease | ||
Yes | 0.86 [0.58; 1.28] | 1.70 [1.15; 2.52] |
No | ||
Haemoglobin | ||
< 9 g/100 mL | 9.13 [3.64; 22.88] | 5.66 [2.12; 15.09] |
9–12 g/100 mL | 1.01 [0.64; 1.59] | 1.32 [0.86; 2.01] |
≥12 g/100 mL | ||
Size of primary lesion | ||
≥30 cm2 | 4.02 [2.62; 6.16] | 3.25 [1.91; 5.50] |
< 30 cm2 | ||
Gleason stage/grade category | ||
> 10 | 9.58 [5.50; 16.67] | 2.22 [1.31; 3.77] |
≥10 | ||
Selection effect ( \( \widehat{\alpha} \) ) | 1.51 [0.89; 2.56] | |