TY - JOUR AU - Dahal, Prabin AU - Guerin, Philippe J. AU - Price, Ric N. AU - Simpson, Julie A. AU - Stepniewska, Kasia PY - 2019 DA - 2019/05/17 TI - Evaluating antimalarial efficacy in single-armed and comparative drug trials using competing risk survival analysis: a simulation study JO - BMC Medical Research Methodology SP - 107 VL - 19 IS - 1 AB - Antimalarial efficacy studies in patients with uncomplicated Plasmodium falciparum are confounded by a new infection (a competing risk event) since this event can potentially preclude a recrudescent event (primary endpoint of interest). The current WHO guidelines recommend censoring competing risk events when deriving antimalarial efficacy. We investigated the impact of considering a new infection as a competing risk event on the estimation of antimalarial efficacy in single-armed and comparative drug trials using two simulation studies. SN - 1471-2288 UR - https://doi.org/10.1186/s12874-019-0748-2 DO - 10.1186/s12874-019-0748-2 ID - Dahal2019 ER -