Evaluating antimalarial efficacy in single-armed and comparative drug trials using competing risk survival analysis: a simulation study

Table 4 Probability of rejecting the null hypothesis at two sided 0.05 level for different sample sizes in simulation study II

	n = 100 subjects per arm		n = 200 subjects per arm		n = 500 subjects per arm		n = 1000 subjects per arm
Scenario	LR	G	LR	G	LR	G	LR	G
1A	0.043	0.042	0.055	0.045	0.047	0.047	0.042	0.040
1B	0.043	0.055	0.052	0.082	0.052	0.119	0.051	0.217
1C	0.041	0.052	0.047	0.052	0.045	0.062	0.044	0.080
2A	0.554	0.548	0.846	0.838	0.997	0.995	1.000	1.000
2B	0.198	0.187	0.391	0.395	0.801	0.804	0.982	0.983
3A	0.501	0.312	0.787	0.543	0.991	0.897	1.000	0.997
3B	0.570	0.653	0.854	0.911	0.996	1.000	1.000	1.000
3C	0.151	0.251	0.328	0.501	0.714	0.903	0.964	0.996
3D	0.231	0.168	0.422	0.353	0.828	0.713	0.988	0.959

ISSN: 1471-2288