Fig. 2

Trials Reporting use of Adaptive Allocation Techniques vs. Pre-specified Analyses over Time. For later study initiation years, trial results were more likely to report pre-specified adjusted analyses. On the contrary, as study start year increased, articles were less likely to report utilization of adaptive allocation techniques over time. We illustrate the proportion along with 95% confidence bands for each grouping of years. Note that the articles reflected here are within the subset of those using covariates in randomization or within the subset of those reporting adjusted analyses